ArticleProceedings of the National Academy of Sciences of the United States of America1986
Tumor necrosis factor enhances eosinophil toxicity to Schistosoma mansoni larvae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 173 citations in OpenAlex.
- From innate to adaptive immune response in muscular dystrophies and skeletal muscle regeneration: the role of lymphocytes.BioMed research international · 2014Review
- Tumour necrosis factor-alpha in nasal allergy.Mediators of inflammation · 1995Article
- Asbestos fibres and man made mineral fibres: induction and release of tumour necrosis factor-alpha from rat alveolar macrophages.Occupational and environmental medicine · 1994Article
- Role of interleukin-5 in enhanced migration of eosinophils from airways of immunized guinea-pigs.British journal of pharmacology · 1994Article
- Involvement of tumor necrosis factor alpha in intracellular multiplication of Legionella pneumophila in human monocytes.Infection and immunity · 1993Article
- Cytokines. 3. Cytokines in asthma.Thorax · 1993Review
- Human eosinophils can express the cytokines tumor necrosis factor-alpha and macrophage inflammatory protein-1 alpha.The Journal of clinical investigation · 1993Article
- Differences in cytokine secretion by intestinal mononuclear cells, peripheral blood monocytes and alveolar macrophages from HIV-infected patients.Clinical and experimental immunology · 1993Article
- Tumour necrosis factor enhances the asbestos-induced production of reactive oxygen metabolites by human polymorphonuclear leucocytes (PMN).Clinical and experimental immunology · 1992Article
- Identification of C3 beta chain as the human serum eosinophil cytotoxicity inhibitor.The Journal of experimental medicine · 1991Article
- Endobronchial allergen challenge in asthma. Demonstration of cellular source of granulocyte macrophage colony-stimulating factor by in situ hybridization.The Journal of clinical investigation · 1991Article
- Evaluation of TNF as antiviral, antibacterial and antiparasitic agent.Biotherapy (Dordrecht, Netherlands) · 1991Review
- Sequential mast cell infiltration and degranulation during experimental carcinogenesis.Journal of cancer research and clinical oncology · 1991Article
- Participation of eosinophils in the toxic oil syndrome.Clinical and experimental immunology · 1990Article
- The tumor necrosis factor receptor and human neutrophil function. Deactivation and cross-deactivation of tumor necrosis factor-induced neutrophil responses by receptor down-regulation.The Journal of clinical investigation · 1990Article
- Tumor necrosis factor alpha/cachectin stimulates eosinophil oxidant production and toxicity towards human endothelium.The Journal of experimental medicine · 1990Article
- Gene expression and production of tumour necrosis factor by a rat basophilic leukaemia cell line (RBL-2H3) with IgE receptor triggering.Immunology · 1990Article
- Alveolar macrophages in AIDS patients: increased spontaneous tumour necrosis factor-alpha production in Pneumocystis carinii pneumonia.Clinical and experimental immunology · 1990Article
- A serum factor that suppresses the cytotoxic function of cytokine-stimulated human eosinophils.The Journal of experimental medicine · 1990Article
- Tumor necrosis factor plays a protective role in experimental murine cutaneous leishmaniasis.The Journal of experimental medicine · 1989Article
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2 authors.
Funding
Abstract
Tumor necrosis factor (TNF) is a monocyte product that kills or inhibits the growth of certain tumor cells. Its cell source and physical characteristics suggest that it is similar to a monokine, eosinophil-cytotoxicity-enhancing factor (M-ECEF), that activates human eosinophil toxicity to Schistosoma mansoni larvae. The availability of recombinant human TNF allowed us to test this possibility. The data show that TNF has no direct effect on the parasites but enhances eosinophil toxicity to the parasites in a dose-dependent fashion. This effect is specific for eosinophils and not neutrophils. TNF and the eosinophil-specific activity of TNF are coeluted with M-ECEF in reversed-phase HPLC. Further, M-ECEF activity in HPLC fractions is reduced by treatment with rabbit anti-TNF antibody and protein A-Sepharose. This demonstrates physical similarity and at least partial immunological identity of TNF and a fraction of M-ECEF. Thus, TNF can enhance eosinophil function and may constitute an important immunological regulatory mechanism. This effect should be considered when TNF is applied clinically.
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