ArticleProceedings of the National Academy of Sciences of the United States of America1986
Cocompartmentation of proteins and K+ within the living cell.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Acute heat stress prior to downhill running may enhance skeletal muscle remodeling.Cell stress & chaperones · 2012Article
- Coherent Behavior and the Bound State of Water and K(+) Imply Another Model of Bioenergetics: Negative Entropy Instead of High-energy Bonds.The open biochemistry journal · 2012Article
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- Article
- Mechanisms of mitochondria-neurofilament interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Substrate modulation of aldolase B binding in hepatocytes.The Biochemical journal · 1996Article
- Effect of non-lytic concentrations of Brij series detergents on the metabolism-independent ion permeability properties of human erythrocytes.Biophysical journal · 1995Article
- Formation of "dark" (argyrophilic) neurons of various origin proceeds with a common mechanism of biophysical nature (a novel hypothesis).Acta neuropathologica · 1992Review
- L-929 cells under hyperosmotic conditions. Water, Na+, and K+.Cell biophysics · 1988Article
- Glycolysis in permeabilized L-929 cells.The Biochemical journal · 1988Article
Corrections and comments
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Monolayer H-50 tissue culture cells were treated with Triton X-100 and Brij 58 nonionic detergents, and their electron microscopic morphology along with the release of the intracellular proteins and K+ were studied. Although Triton X-100 was more effective, both detergents removed the lipoid membranes within 5 min. The mobilization and solubilization of the cytoplasmic and nuclear proteins occurred much faster with Triton X-100 than with Brij 58. In Triton X-100-treated cells, the loss of K+ was complete within 2 min. The loss of K+ from the Brij 58-treated cells was complete only after 10 min and the mobilization of K+ showed sigmoid-type release kinetics. These results support the view that most of K+ and "diffusible" proteins not freely dissolved in the cellular water, but they are cocompartmentalized inside the living cell.
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