Evidence map›Paper›PMID 34565488›Full record

ArticleActa neuropathologica communications2021

Generation of human chronic wasting disease in transgenic mice.

Zerui Wang, Kefeng Qin, Manuel V Camacho, Ignazio Cali, Jue Yuan, Pingping Shen, Justin Greenlee, Qingzhong Kong, James A Mastrianni, Wen-Quan Zou

Open access · goldAbstract read
In one paragraph

Article in Acta neuropathologica communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Novel Prion Protein Gene (bioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Chronic Wasting Disease: State of the Science.Pathogens (Basel, Switzerland) · 2024
    Review
  14. Propagation of PrPCommunications biology · 2023
    Article
  15. Article
  16. Large animal models for chronic wasting disease.Cell and tissue research · 2023
    Review
  17. Review
  18. Vaccines for prion diseases: a realistic goal?Cell and tissue research · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Zerui Wang *Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Kefeng Qin *Department of Neurology and Center for Comprehensive Care and Research On Memory Disorders, The University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
Manuel V Camacho *Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Ignazio Cali *Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Jue YuanDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Pingping ShenDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Justin GreenleeVirus and Prion Research Unit, Agricultural Research Service, National Animal Disease Center, USDA, 1920 Dayton Avenue, Ames, IA, 50010, USA.
Qingzhong KongDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA. qxk2@case.edu.
James A MastrianniDepartment of Neurology and Center for Comprehensive Care and Research On Memory Disorders, The University of Chicago Pritzker School of Medicine, Chicago, IL, USA. jmast@neurology.bsd.uchicago.edu.
Wen-Quan ZouDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA. wxz6@case.edu.
Case Western Reserve University · USUniversity of Chicago · USNational Animal Disease Center · US

Funding

Translational Therapeutics CoreP30AG062428 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI LEVERENZ, JAMES BRUCE · 2019 to 2020
$5.0M
Assessing skin biomarkers for preclinical diagnosis of PD and non-PD ParkinsonismU01NS112010 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI CHEN, SHU G., GUNZLER, STEVEN A. · 2019 to 2023
$3.7M
Role of skin prions in disease transmission and diagnostic testing of human prion diseaseR01NS109532 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KONG, QINGZHONG · 2018 to 2022
$2.9M
Cervid to human prion transmissionR01NS088604 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KONG, QINGZHONG · 2015 to 2018
$1.4M
Conformational properties of misfolded protein aggregates in cases involving the co-occurrence of prion disease and Alzehimer's disease or prion disease and CTEK99AG068359 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI CALI, IGNAZIO · 2020 to 2021
$242k
NIA NIH HHS K99 AG068359NIA NIH HHS P30 AG062428NINDS NIH HHS R01 NS088604NINDS NIH HHS R01 NS109532NINDS NIH HHS R01NS109532
6 · The paper itself

Abstract

Chronic wasting disease (CWD) is a cervid prion disease caused by the accumulation of an infectious misfolded conformer (PrP

Indexed as

DeerPrPSc ProteinsWasting Disease, ChronicAnimalsDisease Models, AnimalHumansMiceMice, TransgenicPrPC ProteinsZoonosesPrPC ProteinsPrPSc ProteinsCellular prion protein (PrPC)Chronic wasting disease (CWD)Prion diseasePrions (PrPSc)Serial protein misfolding cyclic amplification (sPMCA)

Identifiers

PMID34565488
PMCPMC8474769
OpenAlexW3202620415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.