ArticleCancer & metabolism2021
mGWAS identification of six novel single nucleotide polymorphism loci with strong correlation to gastric cancer.
Article in Cancer & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 7 citations in OpenAlex.
- Novel Metabolites Genetically Linked to Salt Sensitivity of Blood Pressure: Evidence from mGWAS in Chinese Population.International journal of molecular sciences · 2025Article
- Exploring the Prognosis-Related Genetic Variation in Gastric Cancer Based on mGWAS.International journal of molecular sciences · 2023Article
- Prognostic Implication of Plasma Metabolites in Gastric Cancer.International journal of molecular sciences · 2023Article
- Polymorphism rs1057147 located in mesothelin gene predicts lymph node metastasis in patients with gastric cancer.Applied microbiology and biotechnology · 2023Article
- Association of lncRNA H19 polymorphisms with cancer susceptibility: An updated meta-analysis based on 53 studies.Frontiers in genetics · 2022Article
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12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMetabolite genome-wide association studies (mGWAS) are key for understanding the genetic regulation of metabolites in complex diseases including cancers. Although mGWAS has revealed hundreds of metabolomics quantitative trait loci (mQTLs) in the general population, data relating to gastric cancer (GC) are still incomplete.
methodsWe identified mQTLs associated with GC by analyzing genome-wide and metabolome-wide datasets generated from 233 GC patients and 233 healthy controls.
resultsTwenty-two metabolites were statistically different between GC cases and healthy controls, and all of them were associated with the risk of gastric cancer. mGWAS analyses further revealed that 9 single nucleotide polymorphisms (SNPs) were significantly associated with 3 metabolites. Of these 9 SNPs, 6 loci were never reported in the previous mGWAS studies. Surprisingly, 4 of 9 SNPs were significantly enriched in genes involved in the T cell receptor signaling pathway.
conclusionsOur study unveiled several novel GC metabolite and genetic biomarkers, which may be implicated in the prevention and diagnosis of gastric cancer.
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