Evidence map›Paper›PMID 34565451›Full record

ArticleStem cell research & therapy2021

Evaluation of the effect of donor weight on adipose stromal/stem cell characteristics by using weight-discordant monozygotic twin pairs.

Miia Juntunen, Sini Heinonen, Heini Huhtala, Aila Rissanen, Jaakko Kaprio, Kirsi Kuismanen, Kirsi H Pietiläinen, Susanna Miettinen, Mimmi Patrikoski

Open access · goldAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Miia JuntunenAdult Stem Cell Group, Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, 33014, Tampere, Finland. miia.juntunen@tuni.fi.ORCID 0000-0001-5282-4376
Sini HeinonenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Heini HuhtalaFaculty of Social Sciences, University of Tampere, Tampere, Finland.
Aila RissanenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Jaakko KaprioInstitute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.
Kirsi KuismanenAdult Stem Cell Group, Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, 33014, Tampere, Finland.
Kirsi H PietiläinenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Susanna Miettinen *Adult Stem Cell Group, Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, 33014, Tampere, Finland.
Mimmi Patrikoski *Adult Stem Cell Group, Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, 33014, Tampere, Finland.
University of Helsinki · FITampere University · FITampere University of Applied Sciences · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdipose stromal/stem cells (ASCs) are promising candidates for future clinical applications. ASCs have regenerative capacity, low immunogenicity, and immunomodulatory ability. The success of future cell-based therapies depends on the appropriate selection of donors. Several factors, including age, sex, and body mass index (BMI), may influence ASC characteristics. Our aim was to investigate the effect of acquired weight on ASC characteristics under the same genetic background using ASCs derived from monozygotic (MZ) twin pairs.

methodsASCs were isolated from subcutaneous adipose tissue from five weight-discordant (WD, within-pair difference in BMI > 3 kg/m

resultsASCs showed low immunogenicity, proliferation, and osteogenic differentiation capacity independent of weight among all donors. ASCs showed a mesenchymal stem cell-like immunophenotype; however, the expression of CD146 was significantly higher in leaner WD twins than in heavier cotwins. ASCs from heavier twins from WD pairs showed significantly greater adipogenic differentiation capacity and higher expression of TNF and lower angiogenic potential compared with their leaner cotwins. ASCs showed immunosuppressive capacity in direct cocultures; however, heavier WD twins showed stronger immunosuppressive capacity than leaner cotwins.

conclusionsOur genetically matched data suggest that a higher weight of the donor may have some effect on ASC characteristics, especially on angiogenic and adipogenic potential, which should be considered when ASCs are used clinically.

Indexed as

Mesenchymal Stem CellsOsteogenesisAdipose TissueCell DifferentiationEndothelial CellsHumansTwins, MonozygoticAdipose stem cellsCell surface markersDifferentiationImmunogenicityImmunosuppressionProliferation

Identifiers

PMID34565451
PMCPMC8474937
OpenAlexW3203295713

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.