Evidence map›Paper›PMID 34565280›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Carnitine is a pharmacological allosteric chaperone of the human lysosomal

Roberta Iacono, Nadia Minopoli, Maria Carmina Ferrara, Antonietta Tarallo, Carla Damiano, Caterina Porto, Sandra Strollo, Véronique Roig-Zamboni, Gianfranco Peluso, Gerlind Sulzenbacher and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Two novelGenes & diseases · 2027
    Article
  2. Review
  3. Article
  4. Article
  5. spJournal of enzyme inhibition and medicinal chemistry · 2022
    Article
  6. Pharmacological Chaperone Therapy for Pompe Disease.Molecules (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Roberta IaconoDepartment of Biology, University of Naples "Federico II", Complesso Universitario di Monte S. Angelo, Naples, Italy.ORCID 0000-0002-3586-4322
Nadia MinopoliTelethon Institute of Genetics & Medicine, Pozzuoli, Italy.
Maria Carmina FerraraInstitute of Biosciences and Bioresources - CNR, Naples, Italy.
Antonietta TaralloTelethon Institute of Genetics & Medicine, Pozzuoli, Italy.
Carla DamianoTelethon Institute of Genetics & Medicine, Pozzuoli, Italy.
Caterina PortoTelethon Institute of Genetics & Medicine, Pozzuoli, Italy.
Sandra StrolloTelethon Institute of Genetics & Medicine, Pozzuoli, Italy.
Véronique Roig-ZamboniCentre National de la Recherche Scientifique (CNRS), Aix-Marseille University, AFMB, Marseille, France.
Gianfranco PelusoResearch Institute on Terrestrial Ecosystems, UOS Naples-CNR, Naples, Italy.
Gerlind SulzenbacherCentre National de la Recherche Scientifique (CNRS), Aix-Marseille University, AFMB, Marseille, France.ORCID 0000-0003-4844-2820
Beatrice Cobucci-PonzanoInstitute of Biosciences and Bioresources - CNR, Naples, Italy.ORCID 0000-0002-8211-2297
Giancarlo ParentiTelethon Institute of Genetics & Medicine, Pozzuoli, Italy.
Marco MoracciDepartment of Biology, University of Naples "Federico II", Complesso Universitario di Monte S. Angelo, Naples, Italy.ORCID 0000-0002-9846-2531
Telethon Institute Of Genetics And Medicine · ITInstitute of Biosciences and Bioresources · ITCentre National de la Recherche Scientifique · FRFederico II University Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pompe disease is an inherited metabolic disorder due to the deficiency of the lysosomal acid

Indexed as

Allosteric Regulationalpha-GlucosidasesCarnitineDose-Response Relationship, DrugGlycoside Hydrolase InhibitorsHumansLysosomesMolecular ChaperonesMolecular StructureStructure-Activity Relationshipalpha-GlucosidasesCarnitineGlycoside Hydrolase InhibitorsMolecular Chaperonescarbohydrate active enzymesglycogen storage disease type 2lysosomal diseaseorphan drugsα-Glucosidase

Identifiers

PMID34565280
PMCPMC8477953
OpenAlexW3203567670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.