Evidence map›Paper›PMID 34565203›Full record

ArticleChronic respiratory disease

Comparison of the sensitivity of patient-reported outcomes for detecting the benefit of biologics in severe asthma.

Michael E Hyland, Joseph W Lanario, Andrew Menzies-Gow, Adel H Mansur, James W Dodd, Stephen J Fowler, Gemma Hayes, Rupert C Jones, Matthew Masoli

Open access · goldAbstract read
In one paragraph

Article in Chronic respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Impact of comorbidities on EQ-5D quality-of-life index in severe asthma.The journal of allergy and clinical immunology. Global · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 1 country.

Michael E Hyland6629Plymouth Marjon University, Plymouth, UK.ORCID 0000-0003-3879-0469
Joseph W LanarioFaculty of Health, 6633University of Plymouth, Plymouth, UK.ORCID 0000-0003-0317-9774
Andrew Menzies-Gow156726Royal Brompton Hospital, London, UK.
Adel H MansurUniversity Hospitals Birmingham and University of Birmingham, 156631Heartlands Hospital, Birmingham, UK.
James W DoddAcademic Respiratory Unit, 159003Southmead Hospital, North Bristol Hospital Trust, Bristol, UK.ORCID 0000-0003-4805-5759
Stephen J FowlerSchool of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre and NIHR Manchester Biomedical Research Centre, 5293Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
Gemma Hayes6634University Hospitals Plymouth NHS Trust, Plymouth, UK.
Rupert C Jones6629Plymouth Marjon University, Plymouth, UK.
Matthew MasoliRoyal Devon and Exeter Hospital, University of Exeter, Exeter, UK.
Plymouth Marjon University · GBHeartlands Hospital · GBManchester Academic Health Science Centre · GBNorth Bristol NHS Trust · GBRoyal Brompton Hospital · GBUniversity Hospitals Plymouth NHS Trust · GBUniversity of Exeter · GBUniversity of Plymouth · GB

Funding

Medical Research Council MR/T005114/1
6 · The paper itself

Abstract

BackgroundThe sensitivity of patient-reported outcomes (PROs) to detect the effects of treatment change depends on the match between the change in items of the PRO and the change that takes place in a sample of people. The aim of this study is to compare the sensitivity of different PROs in detecting changes following the initiation of biologic treatment in asthma.

Indexed as

AsthmaBiological ProductsHumansPatient Reported Outcome MeasuresProspective StudiesPsychometricsQuality of LifeRetrospective StudiesSurveys and QuestionnairesBiological ProductsAsthmaAsthma Control Questionnaire-6EQ5Dmeasurementquality of lifeSevere Asthma Questionnaire

Identifiers

PMID34565203
PMCPMC8477679
OpenAlexW3203946193

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.