ArticleJournal of diabetes investigation2022
Werner syndrome presenting as early-onset diabetes: A case report.
Article in Journal of diabetes investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- A Rare Cause of Acute Pancreatitis: Two Siblings With Werner Syndrome.JCEM case reports · 2025Article
- The identification of a novel mutation (p.I223fs) in WRN associated with Werner syndrome.Endocrine · 2024Article
- Breast cancer in a Hispanic patient with Werner syndrome.Journal of radiology case reports · 2023Article
- Werner syndrome presenting as early-onset diabetes: A case report.Journal of diabetes investigation · 2022Article
- Case Report: A novelFrontiers in endocrinology · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Werner syndrome is a rare autosomal recessive premature progeroid syndrome caused by mutations in the WRN gene. It is characterized by early onset of age-related diseases, such as cataracts, atherosclerosis, diabetes mellitus, osteoporosis and malignancies, in which diabetes often onset in patients' 30-40s. Herein, we report a Chinese patient with Werner syndrome with uncommon early-onset diabetes at 18 years-of-age, who had low body mass index, insulin resistance, negative antibodies of diabetes and early onset of cataracts. Genome sequencing and reverse transcription polymerase chain reaction confirm the diagnosis. A novel heterozygous splice-site mutation in the WRN gene (c.1270-2A>T) was identified. The present case reminds clinicians that when young diabetes patients are encountered, if they are accompanied by premature aging, attention should be paid to identifying the possibility of Werner syndrome based on diagnostic criteria.
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