Evidence map›Paper›PMID 34564901›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2022

Molecular Features of Parkinson's Disease in Patient-Derived Midbrain Dopaminergic Neurons.

Yong Ren, Houbo Jiang, Jiali Pu, Li Li, Jianbo Wu, Yaping Yan, Guohua Zhao, Thomas J Guttuso, Baorong Zhang, Jian Feng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Yong RenDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York, USA.
Houbo JiangDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York, USA.
Jiali PuDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York, USA.
Li LiDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York, USA.
Jianbo WuDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York, USA.
Yaping YanDepartment of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Guohua ZhaoDepartment of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Thomas J GuttusoDepartment of Neurology, State University of New York at Buffalo, Buffalo, New York, USA.ORCID 0000-0001-8708-032X
Baorong ZhangDepartment of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.ORCID 0000-0002-8099-7407
Jian FengDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York, USA.ORCID 0000-0001-7630-8800
University at Buffalo, State University of New York · USSecond Affiliated Hospital of Zhejiang University · CN

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
Molecular Segregation of Parkinson’s Disease by Patient-Derived NeuronsR01NS113763 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI FENG, JIAN · 2020 to 2024
$2.6M
NCI NIH HHS P30 CA016056NINDS NIH HHS R01 NS113763
6 · The paper itself

Abstract

backgroundDespite intense efforts to develop an objective diagnostic test for Parkinson's disease, there is still no consensus on biomarkers that can accurately diagnose the disease.

objectiveIdentification of biomarkers for idiopathic Parkinson's disease (PD) may enable accurate diagnosis of the disease. We tried to find molecular and cellular differences in dopaminergic (DA) neurons derived from healthy subjects and idiopathic PD patients with or without rest tremor at onset.

methodsWe measured the expression of genes controlling dopamine synthesis, sequestration, and catabolism as well as the levels of corresponding metabolites and reactive oxygen species in midbrain DA neurons differentiated from induced pluripotent stem cells (iPSCs) of healthy subjects and PD patients with or without rest tremor.

resultsSignificant differences in DA-related gene expression, metabolites, and oxidative stress were found between midbrain DA neurons derived from healthy subjects and patients with PD. DA neurons derived from PD patients with or without rest tremor at onset exhibited significant differences in the levels of some of these transcripts, metabolites, and oxidative stress.

conclusionThe unique combination of these quantifiable molecular and cellular traits in iPSC-derived midbrain DA neurons can distinguish healthy subjects from idiopathic PD patients and segregate PD patients with or without rest tremor at onset. The strategy may be used to develop an objective diagnostic test for PD.

Indexed as

Induced Pluripotent Stem CellsParkinson DiseaseCell DifferentiationDopaminergic NeuronsHumansMesencephalonParkinson's disease; molecular features; induced pluripotent stem cells; dopamine; metabolism

Identifiers

PMID34564901
PMCPMC8901260
OpenAlexW3203551222

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.