ArticleMedical physics2021
Potential increase in radiation-induced DNA double-strand breaks with higher doses of iodine contrast during coronary CT angiography.
Article in Medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Effect of Deep Learning Image Reconstruction on Image Quality and Pericoronary Fat Attenuation Index.Journal of imaging informatics in medicine · 2025Article
- Trading off Iodine and Radiation Dose in Coronary Computed Tomography.Journal of cardiovascular development and disease · 2025Review
- The burden of radiation exposure in congenital heart disease: the Italian cohort profile and bioresource collection in HARMONIC project.Italian journal of pediatrics · 2024Article
- Application effect of low-dose spiral CT on pulmonary nodules and its diagnostic value for benign and malignant nodules.American journal of translational research · 2023Article
- Potential increase in radiation-induced DNA double-strand breaks with higher doses of iodine contrast during coronary CT angiography.Medical physics · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the contrast media iodine dose dependency of radiation-induced DNA double-strand breaks (DSBs) during a coronary computed tomography angiography (CCTA) scan.
methodsThis prospective patient study was approved by the ethical committee. Between November 2018 and July 2019, 50 patients (31 males and 19 females, mean age 64 years) were included in the study, 45 CCTA and five noncontrast-enhanced (NCE) cardiac computed tomography (CT) patients. A single-heartbeat scan protocol with a patient-tailored contrast media injection protocol was used, administering a patient-specific iodine dose. DNA double-strand breaks were quantified using a γH2AX foci assay on peripheral blood lymphocytes. The net amount of γH2AX/cell was normalized to the individual patient CT dose by the size-specific dose estimate (SSDE). Correlation between the administered and blood-iodine dose and the SSDE normalized amount of DNA DSBs was investigated using a Pearson correlation test.
resultsCCTA patients were scanned with a mean CTDI
conclusionsThis study shows that contrast media iodine dose increases the level of radiation-induced DNA DSBs in peripheral blood lymphocytes in a linear dose-dependent manner with CCTA. Importantly, the level of DNA DSBs can be reduced by lowering the administered iodine dose.
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