Evidence map›Paper›PMID 34564747›Full record

ArticleInsights into imaging2021

A semiquantitative color Doppler ultrasound scoring system for evaluation of synovitis in joints of patients with blood-induced arthropathy.

Ningning Zhang, Sheng Yang, Anne-Fleur Zwagemaker, Aihua Huo, Ying-Jia Li, Fang Zhou, Pamela Hilliard, Sandra Squire, Vanessa Bouskill, Arun Mohanta and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Insights into imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 3 countries.

Ningning ZhangDepartment of Radiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Sheng YangDepartment of Ultrasound, Chengdu Women's and Children's Central Hospital, Sichuan, China.
Anne-Fleur ZwagemakerDepartment of Pediatric Haematology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Aihua HuoDepartment of Radiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Ying-Jia LiDepartment of Radiology, Nanfang Hospital, Guangzhou, China.
Fang ZhouDepartment of Radiology, Nanfang Hospital, Guangzhou, China.
Pamela HilliardDepartment of Rehabilitation, The Hospital for Sick Children, Toronto, ON, Canada.
Sandra SquireService of Physiotherapy, St Paul's Hospital, Providence Health Care, Vancouver, BC, Canada.
Vanessa BouskillDepartment of Paediatrics, University of Toronto, Toronto, ON, Canada.
Arun MohantaDepartment of Diagnostic Imaging, Research Institute, The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, ON, M5G 1X8, Canada.
Alex ZhouDepartment of Diagnostic Imaging, Research Institute, The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, ON, M5G 1X8, Canada.
Jose JarrinDepartment of Diagnostic Imaging, Research Institute, The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, ON, M5G 1X8, Canada.
Runhui WuHaematology/Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Jing SunDepartment of Radiology, Nanfang Hospital, Guangzhou, China.
Brian LukeDivision of Haematology and Transfusion Medicine, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
Rahim MoineddinDivision of Family and Community Medicine, University of Toronto, Toronto, ON, Canada.
Victor S BlanchetteDepartment of Paediatrics, University of Toronto, Toronto, ON, Canada.
Yun Peng *Department of Radiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. ppengyun@hotmail.com.
Andrea S Doria *Department of Diagnostic Imaging, Research Institute, The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, ON, M5G 1X8, Canada. andrea.doria@sickkids.ca.ORCID http://orcid.org/0000-0003-3202-0447
University of Toronto · CACapital Medical University · CNNanfang Hospital · CNAmsterdam University Medical Centers · NLChengdu Women's and Children's Central Hospital · CNChildren's Hospital of Eastern Ontario · CAHospital for Sick Children · CAProvidence Health Care · CA

Funding

Bayer Healthcare Inc ISS#12768CIHR 201302PMHShire-Baxalta H14-21835
6 · The paper itself

Abstract

backgroundIntra-articular bleeds in patients with inherited bleeding disorders lead to active synovitis which may progress to a chronic state over time. We explored the diagnostic value of color Doppler ultrasound in detecting synovitis in boys with bleeding disorders.

resultsSixty boys with hemophilia and 3 boys with type 3 von Willebrand disease aged 5 to 18 years (median 12.3 years) were imaged by gray-scale and color Doppler ultrasound (US) in three centers (Beijing, China [n = 22], Guangzhou, China [n = 12] and Toronto, Canada [n = 29])) in this observational study. Images were independently reviewed by two radiologists blinded to clinical data using a subjective semi-quantitative scoring system and objective measurements of synovial thickness and vascularity. Inter-reader reliability for using subjective versus objective color Doppler US methods for assessing synovial vascularity was excellent for the subjective method and moderate/lower range of substantial for the objective method. Agreement between degree of vascularity on color Doppler and extent of synovial hypertrophy on gray-scale US was overall poor for Canada data and moderate for China data. Correlations between degree of vascularity on color Doppler and synovial hypertrophy on gray-scale US, and clinical constructs (total and itemized HJHS scores and total Pettersson X-ray scores) for assessment of blood-induced arthropathy were all poor.

conclusionColor Doppler US is a valuable scoring method for evaluating reactive synovitis in joints of subjects with inherited bleeding disorders and holds potential for assessing post-bleed reactive synovitis once further information on its association with timing of the joint bleed becomes available in the literature.

Indexed as

Children and adolescents.Color Doppler ultrasoundHemophilic arthropathyMagnetic resonance imaging (MRI)Synovial hypertrophy

Identifiers

PMID34564747
PMCPMC8464640
OpenAlexW3204226361

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.