Evidence map›Paper›PMID 34564706›Full record

Trial reportInternational journal of obesity (2005)2022

CYP1A2 polymorphisms modify the association of habitual coffee consumption with appetite, macronutrient intake, and body mass index: results from an observational cohort and a cross-over randomized study.

Kalliopi G Gkouskou, Georgios Georgiopoulos, Ioannis Vlastos, Evgenia Lazou, Dimitrios Chaniotis, Theodore G Papaioannou, Christos S Mantzoros, Despina Sanoudou, Aristides G Eliopoulos

Registry-linked trialAbstract readObservational StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04514588 (Associations Between Genetic Markers of Caffeine Metabolism, Appetite Hormones and Body Weight), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04514588 naunknown statusnot on this map

Associations Between Genetic Markers of Caffeine Metabolism, Appetite Hormones and Body Weight

TypeinterventionalSponsorGkouskou KalliopiRan2020 to 2022Enrolled70ConditionsFood Consumption and Appetite, Food Habits, CaffeineArmscaffeine consumption
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Coffee Consumption andJournal of personalized medicine · 2024
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. New Discovered Adipokines Associated with the Pathogenesis of Obesity and Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Kalliopi G GkouskouDepartment of Biology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. gkouskoukal@med.uoa.gr.
Georgios GeorgiopoulosSchool of Biomedical Engineering and Imaging Sciences, St Thomas Hospital, King's College, London, UK.
Ioannis VlastosDepartment of Biology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.ORCID http://orcid.org/0000-0002-2741-5877
Evgenia LazouDepartment of Biology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Dimitrios ChaniotisDepartment of Biomedical Sciences, University of West Attica, Athens, Greece.
Theodore G PapaioannouBiomedical Engineering Unit, First Department of Cardiology, Hippokration Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Christos S MantzorosBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.ORCID http://orcid.org/0000-0003-3755-8158
Despina SanoudouClinical Genomics and Pharmacogenomics Unit, 4th Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Aristides G EliopoulosDepartment of Biology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. eliopag@med.uoa.gr.ORCID http://orcid.org/0000-0002-6403-6761
National and Kapodistrian University of Athens · GRBeth Israel Deaconess Medical Center · USSt Thomas' Hospital · GBUniversity of Crete · GRUniversity of West Attica · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesEvidence regarding the influence of coffee on appetite and weight control is equivocal and the influence of covariates, such as genetic variation in caffeine metabolism, remains unknown. Herein, we addressed the novel hypothesis that genetic variation in CYP1A2, a gene responsible for more than 95% of caffeine metabolism, differentially impacts the association of coffee consumption with appetite and BMI among individuals with different genetic predispositions to obesity. SUBJECTS/

methodsA cross-over randomized intervention study involving 18 volunteers assessed the effects of coffee consumption on dietary intake, appetite, and levels of the appetite-controlling hormones asprosin and leptin. Data on habitual coffee intake, BMI, and perceived appetite were obtained from an observational cohort of 284 volunteers using validated questionnaires. Participants were stratified according to a validated genetic risk score (GRS) for obesity and to the -163C > A (rs762551) polymorphism of CYP1A2 as rapid (AA), intermediate (AC), or slow (CC) caffeine metabolizers.

resultsCoffee consumption led to lower energy and dietary fat intake and circulating asprosin levels (P for interaction of rs762551 genotype*coffee consumption=0.056, 0.039, and 0.043, respectively) as compared to slow/intermediate metabolizers. High coffee consumption was more prevalent in rapid compared to slow metabolizers (P = 0.008 after adjustment for age, sex, and BMI) and was associated with lower appetite perception and lower BMI only in rapid metabolizers (P for interaction of rs762551 genotype*coffee consumption = 0.002 and 0.048, respectively). This differential association of rs762551 genotype and coffee consumption with BMI was more evident in individuals at higher genetic risk of obesity (mean adjusted difference in BMI = -5.82 kg/m

conclusionsCYP1A2 rs762551 polymorphism modifies the association of habitual coffee consumption with BMI, in part by influencing appetite, energy intake and circulating levels of the orexigenic hormone asprosin. This association is more evident in subjects with high genetic predisposition to obesity. ClinicalTrials.gov: registered Clinical Trial NCT04514588.

Indexed as

AdolescentAppetiteBody Mass IndexCoffeeCohort StudiesCross-Over StudiesCytochrome P-450 CYP1A2EatingFeeding BehaviorFemaleHealthy VolunteersHumansMalePolymorphism, Single NucleotideYoung AdultCoffeeCYP1A2 protein, humanCytochrome P-450 CYP1A2

Identifiers

PMID34564706
OpenAlexW3203288118

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.