Evidence map›Paper›PMID 34564658›Full record

ArticleToxins2021

Proteomic Identification and Quantification of Snake Venom Biomarkers in Venom and Plasma Extracellular Vesicles.

Nicholas Kevin Willard, Emelyn Salazar, Fabiola Alejandra Oyervides, Cierra Siobhrie Wiebe, Jack Sutton Ocheltree, Mario Cortez, Ricardo Pedro Perez, Harry Markowitz, Anton Iliuk, Elda Eliza Sanchez and 2 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Exosomes - A Boon in Disguise?Indian dermatology online journal · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Nicholas Kevin WillardNational Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX 78363, USA.
Emelyn SalazarNational Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX 78363, USA.ORCID 0000-0001-9996-1116
Fabiola Alejandra OyervidesNational Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX 78363, USA.
Cierra Siobhrie WiebeNational Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX 78363, USA.
Jack Sutton OcheltreeNational Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX 78363, USA.
Mario CortezNational Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX 78363, USA.
Ricardo Pedro PerezOmx Analytics, Kingsville, TX 38363, USA.
Harry MarkowitzTymora Analytical Operations, West Lafayette, IN 47906, USA.
Anton IliukTymora Analytical Operations, West Lafayette, IN 47906, USA.
Elda Eliza SanchezNational Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX 78363, USA.
Montamas SuntravatNational Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX 78363, USA.ORCID 0000-0001-8955-7806
Jacob Anthony GalanNational Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 224, 975 West Avenue B, Kingsville, TX 78363, USA.
Texas A&M University – Kingsville · USTymora Analytical Operations (United States) · USThe King's College · US

Funding

Viper Resource Grant at Texas A&M University-KingsvilleP40OD010960 · OD · TEXAS A&M UNIVERSITY-KINGSVILLE · PI Elda E. Sanchez · 2012 to 2026
$9.2M
The acute effects of snake venom CRiSP toxins on blood and lymphatic endothelial cell permeability: new insights into the pathophysiology of snakebiteR15HL137134 · NHLBI · TEXAS A&M UNIVERSITY-KINGSVILLE · PI SUNTRAVAT, MONTAMAS · 2017 to 2020
$826k
6 · The paper itself

Abstract

The global exploration of snakebites requires the use of quantitative omics approaches to characterize snake venom as it enters into the systemic circulation. These omics approaches give insights into the venom proteome, but a further exploration is warranted to analyze the venom-reactome for the identification of snake venom biomarkers. The recent discovery of extracellular vesicles (EVs), and their critical cellular functions, has presented them as intriguing sources for biomarker discovery and disease diagnosis. Herein, we purified EV's from the snake venom (svEVs) of

Indexed as

CrotalusAnimalsBiomarkersCrotalid VenomsExtracellular VesiclesMiceMice, Inbred BALB CModels, AnimalProteomicsBiomarkersCrotalid VenomsEVtrapextracellular vesiclesproteomicssnake venom biomarkers

Identifiers

PMID34564658
PMCPMC8473211
OpenAlexW3200892985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.