Evidence map›Paper›PMID 34564638›Full record

ArticleToxins2021

New Trends in the Occurrence of Yessotoxins in the Northwestern Adriatic Sea.

Silva Rubini, Sabrina Albonetti, Simonetta Menotta, Antonio Cervo, Emanuele Callegari, Monica Cangini, Sonia Dall'Ara, Erika Baldini, Silvia Vertuani, Stefano Manfredini

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 17 citations in OpenAlex.

  1. The Benthic DinoflagellateMarine drugs · 2025
    Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Silva RubiniExperimental Zooprophylactic Institute of Lombardy and Emilia Romagna, 44124 Ferrara, Italy.ORCID 0000-0002-1764-5804
Sabrina AlbonettiDepartment of Veterinary Medical Sciences, DIMEVET, University of Bologna, Via Tolara di Sopra 50, Ozzano Emilia, 40064 Bologna, Italy.
Simonetta MenottaExperimental Zooprophylactic Institute of Lombardia and Emilia Romagna, Food Chemical Department of Bologna, Via P. Fiorini 5, 40127 Bologna, Italy.ORCID 0000-0002-1077-4785
Antonio CervoDepartment of Veterinary Medical Sciences, DIMEVET, University of Bologna, Via Tolara di Sopra 50, Ozzano Emilia, 40064 Bologna, Italy.
Emanuele CallegariExperimental Zooprophylactic Institute of Lombardy and Emilia Romagna, 44124 Ferrara, Italy.
Monica CanginiNational Reference Laboratory for Marine Biotoxins-Viale A. Vespucci, 2-47042 Cesenatico, Italy.ORCID 0000-0002-5361-4837
Sonia Dall'AraNational Reference Laboratory for Marine Biotoxins-Viale A. Vespucci, 2-47042 Cesenatico, Italy.
Erika BaldiniDepartment of Life Sciences and Biotechnology, Faculty of Medicine, Pharmacy and Prevention, Master Course in Cosmetic Science, Via Fossato di Mortara 17-19, University of Ferrara, 44121 Ferrara, Italy.
Silvia VertuaniDepartment of Life Sciences and Biotechnology, Faculty of Medicine, Pharmacy and Prevention, Master Course in Cosmetic Science, Via Fossato di Mortara 17-19, University of Ferrara, 44121 Ferrara, Italy.
Stefano ManfrediniDepartment of Life Sciences and Biotechnology, Faculty of Medicine, Pharmacy and Prevention, Master Course in Cosmetic Science, Via Fossato di Mortara 17-19, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-1348-4422
Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini" · ITUniversity of Ferrara · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Yessotoxins (YTXs) are polycyclic toxic ether compounds produced by phytoplanktonic dinoflagellates which accumulate in filter-feeding organisms. We know that the water temperature in our areas Northwestern Adriatic Sea is optimal for the growth of potentially toxic algae (around 20 °C). In recent years, these temperatures have remained at these levels for longer and longer periods, probably due to global warming, which has led to an excessive increase in toxin levels. The interruption of mussel harvesting caused by algae negatively affects farmers' revenues and the availability of local fish, causing a major economic loss in Italy's main shellfish sector.

methodsIn the nine years considered, 3359 samples were examined: 1715 marine waters, 73 common clams; 732 mussels; 66 oysters; and 773 veracious clams. Bivalve molluscs were examined for the presence of marine biotoxins, including YTXs, while potentially toxic algae, including those producing YTXs, were searched for and counted in marine waters. The method adopted for the quantification of lipophilic toxins involves the use of an LC-MS/MS system. The enumeration of phytoplankton cells was performed according to the Utermhöl method.

resultsBetween 2012 and 2020, 706 molluscs were tested for YTXs. In total, 246 samples tested positive, i.e., 34.84%. Of the positive samples, 30 exceeded the legal limit.

conclusionIn this regard, it is essential to develop and activate, as soon as possible, an "early warning" system that allows a better control of the production areas of live bivalve molluscs, thus allowing an optimal management of the plants in these critical situations.

Indexed as

DinoflagellidaItalyMarine ToxinsMediterranean SeaMollusk VenomsOxocinsSeawaterMarine ToxinsMollusk VenomsOxocinsyessotoxinglobal warningLC-MS/MSmolluscsstructure-activity relationshipstoxic phytoplanktonYessotoxins

Identifiers

PMID34564638
PMCPMC8471916
OpenAlexW3200213477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.