Evidence map›Paper›PMID 34564533›Full record

ArticleMembranes2021

Red Blood Cell Proteasome in Beta-Thalassemia Trait: Topology of Activity and Networking in Blood Bank Conditions.

Alkmini T Anastasiadi, Vassilis L Tzounakas, Vasiliki-Zoi Arvaniti, Monika Dzieciatkowska, Konstantinos Stamoulis, Marilena E Lekka, Issidora S Papassideri, Angelo D'Alessandro, Anastasios G Kriebardis, Marianna H Antonelou

Open access · goldAbstract read
In one paragraph

Article in Membranes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Alkmini T AnastasiadiDepartment of Biology, School of Science, National and Kapodistrian University of Athens (NKUA), 15784 Athens, Greece.
Vassilis L TzounakasDepartment of Biology, School of Science, National and Kapodistrian University of Athens (NKUA), 15784 Athens, Greece.
Vasiliki-Zoi ArvanitiDepartment of Biology, School of Science, National and Kapodistrian University of Athens (NKUA), 15784 Athens, Greece.
Monika DzieciatkowskaDepartment of Biochemistry and Molecular Genetics, School of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.
Konstantinos StamoulisHellenic National Blood Transfusion Centre, Acharnes, 13677 Athens, Greece.
Marilena E LekkaLaboratory of Biochemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0001-8667-4927
Issidora S PapassideriDepartment of Biology, School of Science, National and Kapodistrian University of Athens (NKUA), 15784 Athens, Greece.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, School of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.ORCID 0000-0002-2258-6490
Anastasios G KriebardisLaboratory of Reliability and Quality Control in Laboratory Hematology (HemQcR), Department of Biomedical Sciences, School of Health & Welfare Sciences, University of West Attica (UniWA), 12243 Egaleo, Greece.ORCID 0000-0003-3915-1829
Marianna H AntonelouDepartment of Biology, School of Science, National and Kapodistrian University of Athens (NKUA), 15784 Athens, Greece.ORCID 0000-0003-3787-3596
National and Kapodistrian University of Athens · GRUniversity of Colorado Anschutz Medical Campus · USUniversity of Ioannina · GRUniversity of West Attica · GR

Funding

The Impact of Oxidative Stress on Erythocyte BiologyR01HL148151 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ALESSANDRO, ANGELO, KARAFIN, MATTHEW S · 2019 to 2022
$8.9M
The role of ferroptosis in red cell aging in vivo and in vitroR01HL146442 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Angelo D'Alessandro, Adam N. Goldfarb · 2019 to 2026
$5.4M
Interactions between the ADORA2b/Sphk1axis and the AE1-Hb switch in red blood cell aging in vivo and in vitroR01HL149714 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI D'ALESSANDRO, ANGELO · 2020 to 2023
$2.6M
MIRAGES: Metabolic Investigation of Red blood cells as a function of Aging, Genetics, Environment, and StorageR21HL150032 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI D'ALESSANDRO, ANGELO · 2020 to 2021
$414k
Hellenic Foundation for Research and Innovation (HFRI) and the General Secretariat for Research and Innovation (GSRI) 2032NHLBI NIH HHS R01 HL146442NHLBI NIH HHS R01 HL148151NHLBI NIH HHS R01 HL149714NHLBI NIH HHS R21 HL150032
6 · The paper itself

Abstract

Proteasomes are multi-catalytic complexes with important roles in protein control. Their activity in stored red blood cells (RBCs) is affected by both storage time and the donor's characteristics. However, apart from their abundancy in the membrane proteome, not much is known about their topology, activity, and networking during the storage of RBCs from beta-thalassemia trait donors (βThal

Indexed as

activitybeta thalassemia traitinteractomemembrane localizationproteasomeproteostasisred blood cellregulationstorage

Identifiers

PMID34564533
PMCPMC8466122
OpenAlexW3201056610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.