Evidence map›Paper›PMID 34564431›Full record

ArticleMetabolites2021

Metabolomics Reveals Process of Allergic Rhinitis Patients with Single- and Double-Species Mite Subcutaneous Immunotherapy.

Peiyan Zheng, Guanyu Yan, Yida Zhang, Huimin Huang, Wenting Luo, Mingshan Xue, Na Li, Jian-Lin Wu, Baoqing Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. A circulating odd-chain fatty acid biomarker signature discriminates pediatric allergic rhinitis with asthma from related allergic airway phenotypes.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. [Chinese expert consensus on the evaluation of allergen-specific immunotherapy outcomes（Wuhan, 2025）].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Immunomodulatory metabolites in IgE-mediated food allergy and oral immunotherapy outcomes based on metabolomic profiling.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Metabolomics in Otorhinolaryngology.Frontiers in molecular biosciences · 2022
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Peiyan ZhengDepartment of Allergy and Clinical Immunology, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institue of Respiratory Health, Guangzhou 510120, China.ORCID 0000-0002-8795-4899
Guanyu YanDepartment of Allergy and Clinical Immunology, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institue of Respiratory Health, Guangzhou 510120, China.
Yida ZhangDepartment of Allergy and Clinical Immunology, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institue of Respiratory Health, Guangzhou 510120, China.
Huimin HuangDepartment of Allergy and Clinical Immunology, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institue of Respiratory Health, Guangzhou 510120, China.
Wenting LuoDepartment of Allergy and Clinical Immunology, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institue of Respiratory Health, Guangzhou 510120, China.
Mingshan XueDepartment of Allergy and Clinical Immunology, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institue of Respiratory Health, Guangzhou 510120, China.
Na LiState Key Laboratory for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macao 999078, China.
Jian-Lin WuState Key Laboratory for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macao 999078, China.
Baoqing SunDepartment of Allergy and Clinical Immunology, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institue of Respiratory Health, Guangzhou 510120, China.
First Affiliated Hospital of Guangzhou Medical University · CNMacau University of Science and Technology · MO

Funding

Bureau of traditional Chinese Medicine Scientific Research Project of Guangdong 20192048Guangdong Science and Technology Fund 2020B1111300001National Natural Science Foundation of China 81871736, 81601394, 81572063Research Project of First Affiliated Hospital of Guangzhou Medical University ZH201915
6 · The paper itself

Abstract

Allergen immunotherapy (AIT) is the only treatment that can change the course of allergic diseases. However, there has not been any research on metabolic reactions in relation to AIT with single or mixed allergens. In this study, patients with allergic rhinitis caused by

Indexed as

allergen immunotherapyallergic rhinitishydroxyeicosatetraenoic acid

Identifiers

PMID34564431
PMCPMC8471092
OpenAlexW3197643950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.