Evidence map›Paper›PMID 34564402›Full record

ReviewMetabolites2021

Salivary Metabolomics for Diagnosis and Monitoring Diseases: Challenges and Possibilities.

Eelis Hyvärinen, Minttu Savolainen, Jopi J W Mikkonen, Arja M Kullaa

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eelis HyvärinenDepartment of Oral Medicine, Institute of Dentistry, School of Medicine, Kuopio Campus, University of Eastern Finland, FI-70211 Kuopio, Finland.
Minttu SavolainenDepartment of Oral Medicine, Institute of Dentistry, School of Medicine, Kuopio Campus, University of Eastern Finland, FI-70211 Kuopio, Finland.
Jopi J W MikkonenDepartment of Oral Medicine, Institute of Dentistry, School of Medicine, Kuopio Campus, University of Eastern Finland, FI-70211 Kuopio, Finland.ORCID 0000-0001-8535-0875
Arja M KullaaDepartment of Oral Medicine, Institute of Dentistry, School of Medicine, Kuopio Campus, University of Eastern Finland, FI-70211 Kuopio, Finland.ORCID 0000-0001-8198-8185

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Saliva is a useful biological fluid and a valuable source of biological information. Saliva contains many of the same components that can be found in blood or serum, but the components of interest tend to be at a lower concentration in saliva, and their analysis demands more sensitive techniques. Metabolomics is starting to emerge as a viable method for assessing the salivary metabolites which are generated by the biochemical processes in elucidating the pathways underlying different oral and systemic diseases. In oral diseases, salivary metabolomics has concentrated on periodontitis and oral cancer. Salivary metabolites of systemic diseases have been investigated mostly in the early diagnosis of different cancer, but also neurodegenerative diseases. This mini-review article aims to highlight the challenges and possibilities of salivary metabolomics from a clinical viewpoint. Furthermore, applications of the salivary metabolic profile in diagnosis and prognosis, monitoring the treatment success, and planning of personalized treatment of oral and systemic diseases are discussed.

Indexed as

mass spectrometrymetabolomicsNMR spectrometryoral diseasesalivasystemic disease

Identifiers

PMID34564402
PMCPMC8469343

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.