Evidence map›Paper›PMID 34564381›Full record

ArticleMetabolites2021

Low Levels of Few Micronutrients May Impact COVID-19 Disease Progression: An Observational Study on the First Wave.

Teresa-Maria Tomasa-Irriguible, Lara Bielsa-Berrocal, Luisa Bordejé-Laguna, Cristina Tural-Llàcher, Jaume Barallat, Josep-Maria Manresa-Domínguez, Pere Torán-Monserrat

Abstract read
In one paragraph

Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Serum zinc level independently predicts need for inpatient intubation among patients hospitalized with COVID-19: A prospective observational study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Observational
  4. Article
  5. Vitamin A and Its Related Diseases.Food science & nutrition · 2025
    Review
  6. What do we know about micronutrients in critically ill patients? A narrative review.JPEN. Journal of parenteral and enteral nutrition · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Impact of lifestyle factors on dietary vitamin BThe British journal of nutrition · 2023
    Article
  12. Review
  13. Observational
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Teresa-Maria Tomasa-IrriguibleIntensive Care Unit, University Hospital Germans Trias i Pujol, 08916 Badalona, Spain.ORCID 0000-0001-8033-8527
Lara Bielsa-BerrocalIntensive Care Unit, University Hospital Germans Trias i Pujol, 08916 Badalona, Spain.
Luisa Bordejé-LagunaIntensive Care Unit, University Hospital Germans Trias i Pujol, 08916 Badalona, Spain.ORCID 0000-0003-4129-7309
Cristina Tural-LlàcherInternal Medicine Department, University Hospital Germans Trias i Pujol, 08916 Badalona, Spain.
Jaume BarallatBiochemical Department, University Hospital Germans Trias i Pujol, 08916 Badalona, Spain.ORCID 0000-0003-3493-5958
Josep-Maria Manresa-DomínguezNorth Metropolitan Research Support Unit, Jordi Gol i Gurina Foundation Institute for Research in Primary Health Care (IDIAPJGol), 08303 Mataró, Spain.ORCID 0000-0001-8306-5798
Pere Torán-MonserratNorth Metropolitan Research Support Unit, Jordi Gol i Gurina Foundation Institute for Research in Primary Health Care (IDIAPJGol), 08303 Mataró, Spain.ORCID 0000-0002-9865-7427

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report an observational study performed between March and May 2020 in a Spanish university hospital during the SARS-CoV-2 pandemic. The main objective was to analyse the association between the levels of micronutrients in severe COVID-19 patients and their outcome. Adult patients with a positive polymerase-chain-reaction (PCR) for SARS-CoV-2 in the nasopharyngeal swab or in tracheal aspirate culture in the case of intubation were included. Micronutrient data were obtained from plasma analysis of a standard nutritional assessment performed within the first 24 h of hospital admission. Vitamins A, B

Indexed as

coronavirusCOVID-19critical illnessmicronutrientsoutcomeSARS-CoV-2trace elementsvitamins

Identifiers

PMID34564381
PMCPMC8467487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.