Evidence map›Paper›PMID 34564325›Full record

ArticleSports (Basel, Switzerland)2021

Reduced L-Arginine and L-Arginine-ADMA-Ratio, and Increased SDMA after Norseman Xtreme Triathlon.

Christoffer Nyborg, Martin Bonnevie-Svendsen, Helene Støle Melsom, Jørgen Melau, Ingebjørg Seljeflot, Jonny Hisdal

Open access · goldAbstract read
In one paragraph

Article in Sports (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Christoffer NyborgInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway.ORCID 0000-0002-6777-0670
Martin Bonnevie-SvendsenInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway.
Helene Støle MelsomInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway.
Jørgen MelauInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway.ORCID 0000-0002-3860-3988
Ingebjørg SeljeflotInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway.ORCID 0000-0003-4071-3358
Jonny HisdalInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway.
Oslo University Hospital · NO

Funding

Aker BioMarine Antarctic AS
6 · The paper itself

Abstract

Endothelial vasodilatory function is dependent on the NO synthesis from L-arginine by endothelial NO-synthetase (eNOS). eNOS can be inhibited by asymmetric dimethylarginine (ADMA) by competitive inhibition on the binding site, and symmetric dimethylarginine (SDMA) can reduce the L-arginine availability intracellularly through competing for transport over the cellular membrane. To study the NO synthesis after prolonged exercise, we assessed circulatory L-arginine, the L-arginine/ADMA ratio, and SDMA before, after, and on the day after the Norseman Xtreme triathlon, an Ironman distance triathlon. We found significantly reduced levels of L-arginine and the L-arginine/ADMA ratio and increased levels of SDMA after the race (all

Indexed as

ADMAironmanL-arginineNOSDMAtriathlon

Identifiers

PMID34564325
PMCPMC8472968
OpenAlexW3197071922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.