Evidence map›Paper›PMID 34564149›Full record

ArticleMarine drugs2021

The Toxicology of Native Fucosylated Glycosaminoglycans and the Safety of Their Depolymerized Products as Anticoagulants.

Lisha Lin, Sujuan Li, Na Gao, Weili Wang, Taocui Zhang, Lian Yang, Xingzhi Yang, Dan Luo, Xu Ji, Jinhua Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Prospective bacterial and fungal sources of hyaluronic acid: A review.Computational and structural biotechnology journal · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Lisha LinState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Sujuan LiState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Na GaoSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Weili WangState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Taocui ZhangState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Lian YangState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Xingzhi YangState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Dan LuoCollege of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650201, China.
Xu JiSchool of Chemical Science and Technology, Yunnan University, Kunming 650201, China.
Jinhua ZhaoSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Kunming Institute of Botany · CNChinese Academy of Sciences · CNSouth Central University for Nationalities · CNUniversity of Chinese Academy of Sciences · CNYunnan University · CNYunnan University of Traditional Chinese Medicine · CN

Funding

National Natural Science Foundation of China 81773737, 82073725, 81773374Yunnan Provincial Science and Technology Department in China 2019ZF011-2
6 · The paper itself

Abstract

Fucosylated glycosaminoglycan (FG) from sea cucumber is a potent anticoagulant by inhibiting intrinsic coagulation tenase (iXase). However, high-molecular-weight FGs can activate platelets and plasma contact system, and induce hypotension in rats, which limits its application. Herein, we found that FG from

Indexed as

AnimalsAnticoagulantsBlood CoagulationBlood PressureFucoseGlycosaminoglycansHeartHeart RateLungMalePlatelet ActivationPulmonary EmbolismRatsRats, Sprague-DawleyRespirationSea CucumbersAnticoagulantsFucoseGlycosaminoglycansanticoagulantcontact activationfucosylated glycosaminoglycanhypotensionplatelet aggregationpulmonary embolism

Identifiers

PMID34564149
PMCPMC8467514
OpenAlexW3198399013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.