Evidence map›Paper›PMID 34564146›Full record

ReviewMarine drugs2021

Marine Algae-Derived Bioactive Compounds: A New Wave of Nanodrugs?

Farid Menaa, Udari Wijesinghe, Gobika Thiripuranathar, Norah A Althobaiti, Aishah E Albalawi, Barkat Ali Khan, Bouzid Menaa

Abstract readReview
In one paragraph

Review in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

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  15. Marine drugs · 2025
    Article
  16. Review
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Farid MenaaDepartment of Internal Medicine and Nanomedicine, Fluorotronics-CIC, San Diego, CA 92037, USA.ORCID 0000-0002-0258-7322
Udari WijesingheInstitute of Chemistry Ceylon, College of Chemical Sciences, Rajagiriya 10107, Sri Lanka.ORCID 0000-0001-5422-7321
Gobika ThiripuranatharInstitute of Chemistry Ceylon, College of Chemical Sciences, Rajagiriya 10107, Sri Lanka.ORCID 0000-0002-0904-9519
Norah A AlthobaitiBiology Department, College of Science and Humanities, Shaqra University, Al Quwaiiyah 19257, Saudi Arabia.ORCID 0000-0001-6893-5521
Aishah E AlbalawiBiology Department, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0002-7695-8691
Barkat Ali KhanDepartment of Pharmacy, Gomal University, Dera Ismail Khan 29050, Pakistan.ORCID 0000-0003-4920-1770
Bouzid MenaaDepartment of Internal Medicine and Nanomedicine, Fluorotronics-CIC, San Diego, CA 92037, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Marine algae are rich in bioactive nutraceuticals (e.g., carbohydrates, proteins, minerals, fatty acids, antioxidants, and pigments). Biotic (e.g., plants, microorganisms) and abiotic factors (e.g., temperature, pH, salinity, light intensity) contribute to the production of primary and secondary metabolites by algae. Easy, profitable, and sustainable recovery methods include novel solid-liquid and liquid-liquid extraction techniques (e.g., supercritical, high pressure, microwave, ultrasound, enzymatic). The spectacular findings of algal-mediated synthesis of nanotheranostics has attracted further interest because of the availability of microalgae-based natural bioactive therapeutic compounds and the cost-effective commercialization of stable microalgal drugs. Algal extracts can serve as stabilizing/capping and reducing agents for the synthesis of thermodynamically stable nanoparticles (NPs). Different types of nanotherapeutics have been synthesized using physical, chemical, and biological methods. Marine algae are a fascinating source of lead theranostics compounds, and the development of nanotheranostics has been linked to enhanced drug efficacy and safety. Indeed, algae are remarkable nanobiofactories, and their pragmatic properties reside in their (i) ease of handling; (ii) capacity to absorb/accumulate inorganic metallic ions; (iii) cost-effectiveness; and (iv) capacity of eco-friendly, rapid, and healthier synthesis of NPs. Preclinical and clinical trials shall enable to really define effective algal-based nanotherapies. This review aims to provide an overview of the main algal compounds that are nutraceuticals and that can be extracted and purified for nanotheranostic purposes.

Indexed as

AnimalsBiological ProductsChlorophytaHumansNanomedicinePhaeophyceaeRhodophytaSeaweedBiological Productsalternative and complementary medicinebioactive compoundsdiabetesinnovationmarine algaemarine drugsnanotheranosticsneurodegenerative diseases

Identifiers

PMID34564146
PMCPMC8469996

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.