Evidence map›Paper›PMID 34564083›Full record

ReviewJournal of developmental biology2021

The Role of RNA-Binding Proteins in Vertebrate Neural Crest and Craniofacial Development.

Thomas E Forman, Brenna J C Dennison, Katherine A Fantauzzo

Open access · goldAbstract readReview
In one paragraph

Review in Journal of developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Thomas E FormanDepartment of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-8912-3503
Brenna J C DennisonDepartment of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-7166-7246
Katherine A FantauzzoDepartment of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-0365-4168
University of Colorado Anschutz Medical Campus · US

Funding

Medical Scientist Training ProgramT32GM008497 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI WILSON, CARA C. · 1993 to 2022
$15.2M
Characterization of PDGFR dimer-specific dynamics in the craniofacial mesenchymeR01DE027689 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI FANTAUZZO, KATHERINE ANN · 2018 to 2022
$2.0M
Characterization of PDGFR dimer-specific dynamics in the craniofacial mesenchymeK02DE028572 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI FANTAUZZO, KATHERINE ANN · 2019 to 2023
$627k
Srsf3-mediated alternative RNA splicing in the facial mesenchymeF31DE029364 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI DENNISON, BRENNA JO CLAY · 2020 to 2021
$56k
NIDCR NIH HHS F31 DE029364NIDCR NIH HHS F31DE029364NIDCR NIH HHS K02 DE028572NIDCR NIH HHS K02DE028572NIDCR NIH HHS R01 DE027689NIDCR NIH HHS R01DE027689NIGMS NIH HHS T32 GM008497
6 · The paper itself

Abstract

Cranial neural crest (NC) cells delaminate from the neural folds in the forebrain to the hindbrain during mammalian embryogenesis and migrate into the frontonasal prominence and pharyngeal arches. These cells generate the bone and cartilage of the frontonasal skeleton, among other diverse derivatives. RNA-binding proteins (RBPs) have emerged as critical regulators of NC and craniofacial development in mammals. Conventional RBPs bind to specific sequence and/or structural motifs in a target RNA via one or more RNA-binding domains to regulate multiple aspects of RNA metabolism and ultimately affect gene expression. In this review, we discuss the roles of RBPs other than core spliceosome components during human and mouse NC and craniofacial development. Where applicable, we review data on these same RBPs from additional vertebrate species, including chicken,

Indexed as

craniofacial developmentneural crestRNA-binding protein

Identifiers

PMID34564083
PMCPMC8482138
OpenAlexW3198504215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.