Evidence map›Paper›PMID 34563917›Full record

ArticlePhysiotherapy2021

Feasibility and benefits of a structured prehabilitation programme prior to autologous stem cell transplantation (ASCT) in patients with myeloma; a prospective feasibility study.

Susan Mawson, Carol Keen, Julie Skilbeck, Helen Ross, Lauren Smith, Joanne Dixey, Stephen J Walters, Rebecca Simpson, Diana M Greenfield, John A Snowden

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03135925 (Is it Feasible to Conduct a Randomised Controlled Trial of Pre Transplant Exercise), which is not on this map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03135925 nacompletednot on this map

Is it Feasible to Conduct a Randomised Controlled Trial of Pre Transplant Exercise (Pre-habilitation) for Multiple Myeloma Patients Awaiting Autologous Stem Cell Transplantation?

TypeinterventionalSponsorSheffield Teaching Hospitals NHS Foundation TrustRan2016 to 2017Enrolled23ConditionsMyelomaArmsSupervised Exercise Program
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Prehabilitation to improve function after autologous stem cell transplantation: A pilot randomized controlled trial (PIRATE).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
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  16. Enablers and barriers to referral and delivery of multidisciplinary prehabilitation in the autologous stem cell transplant population: a theory-based interview study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  17. Article
  18. Article
  19. Fitness and frailty in myeloma.Hematology. American Society of Hematology. Education Program · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Susan MawsonSchool of Health and Related Research, University of Sheffield, 30 Regent Street, Sheffield S1 4DA, UK. Electronic address: s.mawson@sheffield.ac.uk.
Carol KeenSheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield S10 2JF, UK. Electronic address: Carol.Keen@nhs.net.
Julie SkilbeckDepartment of Nursing and Midwifery, Sheffield Hallam University, Howard Street, Sheffield S1 1WB, UK. Electronic address: J.Skilbeck@shu.ac.uk.
Helen RossSheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield S10 2JF, UK. Electronic address: Helen.ross9@nhs.net.
Lauren SmithSheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield S10 2JF, UK. Electronic address: Lauren.smith38@nhs.net.
Joanne DixeySheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield S10 2JF, UK. Electronic address: Joanne.Dixey@nhs.net.
Stephen J WaltersSchool of Health and Related Research, University of Sheffield, 30 Regent Street, Sheffield S1 4DA, UK. Electronic address: s.j.walters@sheffield.ac.uk.
Rebecca SimpsonSchool of Health and Related Research, University of Sheffield, 30 Regent Street, Sheffield S1 4DA, UK. Electronic address: r.simpson@sheffield.ac.uk.
Diana M GreenfieldSheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield S10 2JF, UK; Department of Oncology and Metabolism, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK. Electronic address: Diana.greenfield@nhs.net.
John A SnowdenSheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield S10 2JF, UK; Department of Oncology and Metabolism, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK. Electronic address: John.Snowden1@nhs.net.
University of Sheffield · GBRoyal Hallamshire Hospital · GBSheffield Teaching Hospitals NHS Foundation Trust · GBSheffield Hallam University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence supports the benefits of exercise-based rehabilitation in promoting recovery in myeloma patients following autologous stem-cell transplantation (ASCT). However, 'prehabilitation' has never been evaluated prior to ASCT, despite evidence of effectiveness in other cancers. Utilising a mixed method approach the authors investigated the feasibility of a mixed strength and cardiovascular exercise intervention pre-ASCT. Quantitative data were collected to determine feasibility targets; rates of recruitment, adherence and adverse events, including 6minute walking distance (6MWD) test and patient reported outcome measures (PROMs). Qualitative interviews were undertaken with a purposive sample of patients to capture their experiences of the study and the intervention. The authors recruited 23 patients who attended a mean percentage of 75% scheduled exercise sessions. However, retention rates were limited, with only 14/23 (62%) completing the programme. In these patients, the 6MWD increased from a mean of 346 to 451m (i.e. by 105m, 95% CI 62 to 148m) with no serious adverse events. Whist participants found the exercise programme acceptable and reported improvement in their physical fitness and overall mental health and wellbeing prior to ASCT, the study identified challenges in hospital attendance for the prehabilitation schedule whilst receiving induction or re-induction chemotherapy. Evaluation of digitally-enhanced directed but remote prehabilitation models for this patient group is warranted. Trial registration number NCT03135925.

Indexed as

Hematopoietic Stem Cell TransplantationMultiple MyelomaFeasibility StudiesHumansPreoperative ExerciseProspective StudiesTransplantation, AutologousAutologous stem-cell transplantationExercise-based rehabilitationPrehabilitationPROMs

Identifiers

PMID34563917
PMCPMC8612275
OpenAlexW3189947926

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.