Evidence map›Paper›PMID 34563707›Full record

ReviewInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021

COVID-19 pandemic: lessons learned from more than a century of pandemics and current vaccine development for pandemic control.

Philippe Buchy, Yves Buisson, Otavio Cintra, Dominic E Dwyer, Michael Nissen, Raul Ortiz de Lejarazu, Eskild Petersen

Open access · goldAbstract readReview
In one paragraph

Review in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Histopathological Evaluation of the Pericardium in CABG Patients With and Without Prior SARS-CoV-2 Infection: A Prospective Observational Study.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Observational
  4. Article
  5. Article
  6. Article
  7. New COVID-19 vaccination recommendations in Spain: Optimizing for next seasons.Enfermedades infecciosas y microbiologia clinica · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Clinical microbiology reviews · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. A comparison between SARS-CoV-1 and SARS-CoV2: an update on current COVID-19 vaccines.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 6 countries.

Philippe BuchyGSK, Singapore, Singapore. Electronic address: philippe.x.buchy@gsk.com.
Yves BuissonAcadémie nationale de médecine, Paris, France. Electronic address: yvesbuisson@hotmail.com.
Otavio CintraGSK, Rio de Janeiro, Brazil. Electronic address: otavio.a.cintra@gsk.com.
Dominic E DwyerNew South Wales Health Pathology - Institute of Clinical Pathology and Medical Research, Westmead Hospital, New South Wales, Australia. Electronic address: dominic.dwyer@sydney.edu.au.
Michael NissenConsultant in Infectious Diseases, University of Queensland, Brisbane, Australia. Electronic address: theniss@uq.edu.au.
Raul Ortiz de LejarazuScientific Advisor & Emeritus director at Valladolid NIC (National Influenza Centre) Spain, School of Medicine, Avd Ramón y Cajal s/n 47005 Valladolid, Spain. Electronic address: lejarazu@gmail.com.
Eskild PetersenEuropean Society for Clinical Microbiology and Infectious Diseases, Basel, Switzerland; Department of Molecular Medicine, The University of Pavia, Pavia, Italy; Department of Clinical, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: eskild.petersen@gmail.com.
Aarhus University · DKAcadémie Nationale de Médecine · FRGlaxoSmithKline (Brazil) · BRThe University of Queensland · AUWestmead Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pandemic dynamics and health care responses are markedly different during the COVID-19 pandemic than in earlier outbreaks. Compared with established infectious disease such as influenza, we currently know relatively little about the origin, reservoir, cross-species transmission and evolution of SARS-CoV-2. Health care services, drug availability, laboratory testing, research capacity and global governance are more advanced than during 20th century pandemics, although COVID-19 has highlighted significant gaps. The risk of zoonotic transmission and an associated new pandemic is rising substantially. COVID-19 vaccine development has been done at unprecedented speed, with the usual sequential steps done in parallel. The pandemic has illustrated the feasibility of this approach and the benefits of a globally coordinated response and infrastructure. Some of the COVID-19 vaccines recently developed or currently in development might offer flexibility or sufficiently broad protection to swiftly respond to antigenic drift or emergence of new coronaviruses. Yet many challenges remain, including the large-scale production of sufficient quantity of vaccines, delivery of vaccines to all countries and ensuring vaccination of relevant age groups. This wide vaccine technology approach will be best employed in tandem with active surveillance for emerging variants or new pathogens using antigen mapping, metagenomics and next generation sequencing.

Indexed as

COVID-19PandemicsCOVID-19 VaccinesHumansSARS-CoV-2COVID-19 VaccinesCOVID-19pandemicSARS-CoV-2vaccine

Identifiers

PMID34563707
PMCPMC8459551
OpenAlexW3201667608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.