Evidence map›Paper›PMID 34563570›Full record

ArticleAnnals of epidemiology2021

Estimating the joint effect of diabetes and subsequent depressive symptoms on mortality among older latinos.

Kosuke Inoue, Elizabeth Rose Mayeda, Roch Nianogo, Kimberly Paul, Yu Yu, Mary Haan, Beate Ritz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Kosuke InoueDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA; Department of Social Epidemiology, Graduate School of Medicine, Kyoto University, Japan.
Elizabeth Rose MayedaDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA.
Roch NianogoDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA.
Kimberly PaulDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA.
Yu YuDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA.
Mary HaanDepartment of Epidemiology & Biostatistics, School of Medicine, UCSF, San Francisco, CA.
Beate RitzDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA; Department of Environmental Health Sciences, UCLA Fielding School of Public Health, Los Angeles, CA; Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA. Electronic address: britz@ucla.edu.
UCLA Health · USKyoto University · JPUniversity of California, Los Angeles · USUniversity of California, San Francisco · US

Funding

EPIDEMIOLOGY OF FUNCTIONAL STATUS IN ELDERLY HISPANICSR01AG012975 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAAN, MARY N · 1997 to 2015
$13.8M
Environment and cognitive decline in older HispanicsR01ES023451 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HAAN, MARY N, RITZ, BEATE R. · 2015 to 2017
$1.8M
Diabetes in older Latinos, stress and brain changesR01DK060753 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAAN, MARY N. · 2002 to 2004
$1.4M
Racial Disparities in Alzheimer's Disease and Related Dementias: The Role of Blood Pressure Throughout AdulthoodR00AG053410 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYEDA, ELIZABETH ROSE · 2018 to 2020
$710k
Epidemiology of Hypertension and Obesity in Older Mexican AmericansR03AG033751 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAAN, MARY N · 2010 to 2011
$124k
Effects of Chronic Kidney Disease on Cardiovascular Disease and Dementia Among People with Diabetes: Causal Modeling with Machine Learning ApproachF99DK126119 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI INOUE, KOSUKE · 2020 to 2020
$34k
NIA NIH HHS R00 AG053410NIA NIH HHS R01 AG012975NIA NIH HHS R03 AG033751NIDDK NIH HHS F99 DK126119NIDDK NIH HHS R01 DK060753NIEHS NIH HHS R01 ES023451
6 · The paper itself

Abstract

purposeDiabetes and depression are risk factors for cardiovascular disease, but the evidence about their interaction effect on long-term health outcomes among Latinos is lacking. We aimed to investigate the joint association of diabetes and subsequent depressive symptoms with mortality among older Latinos, an understudied racial/ethnic group with high prevalence of diabetes.

methodsThis study included 1,495 adults from the Sacramento Area Latino Study on Aging. We employed Cox proportional-hazards models to estimate the adjusted hazard ratios [aHRs] for cardiovascular and all-cause mortality according to diabetes status at enrollment and depressive symptoms a year after the enrollment. We used marginal structural models to adjust for time-varying confounders.

resultsThe mean age (standard deviation) of participants was 70 (6.6) years. Over follow-up (median 7.7 years), diabetes and depressive symptoms were individually associated with increased risk of cardiovascular mortality (diabetes, aHR[95% CI]=2.13[1.60-2.84]; depressive symptoms, aHR[95% CI]=1.62[1.09-2.39]) and all-cause mortality (diabetes, aHR[95% CI]=1.92[1.53-2.41]; depressive symptoms, aHR[95% CI]=1.41[1.02-1.94]). After adjusting for time-varying confounders, we found a multiplicative interaction between diabetes and subsequent depressive symptoms for cardiovascular mortality (aHR[95% CI]=2.94[1.07-8.39]), but not all-cause mortality (aHR[95% CI]=1.80[0.81-4.35]).

conclusionsUsing a longitudinal cohort of community-dwelling older Latinos, we found that diabetes and subsequent depressive symptoms were jointly associated with increased risk of cardiovascular mortality.

Indexed as

Cardiovascular DiseasesDiabetes MellitusAdultAgedDepressionHispanic or LatinoHumansProportional Hazards ModelsRisk FactorsCardiovascular mortalityDepressionDiabetesLatinosLongitudinal studyMarginal structural model

Identifiers

PMID34563570
PMCPMC11232658
OpenAlexW3201808280

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.