Evidence map›Paper›PMID 34563559›Full record

Trial reportBrazilian journal of anesthesiology (Elsevier)

Effects of Plasma-Lyte.½ and 0.9% saline in renal function after deceased-donor kidney transplant: a randomized controlled trial.

Paulo do Nascimento Junior, Lucas Esteves Dohler, Cindy Midori Uchida Ogawa, Lu Ís Gustavo Modelli de Andrade, Leandro Gobbo Braz, Norma Sueli Pinheiro M Dolo

Open access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brazilian journal of anesthesiology (Elsevier). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Paulo do Nascimento JuniorUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Departamento de Especialidades Cir..rgicas e Anestesiologia, Botucatu, SP, Brazil. Electronic address: paulo.nascimento-junior@unesp.br.
Lucas Esteves DohlerUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Departamento de Especialidades Cir..rgicas e Anestesiologia, Botucatu, SP, Brazil.
Cindy Midori Uchida OgawaUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Departamento de Especialidades Cir..rgicas e Anestesiologia, Botucatu, SP, Brazil.
Lu Ís Gustavo Modelli de AndradeUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Hospital das Cl.ínicas, Programa de Transplante Renal, Botucatu, SP, Brazil.
Leandro Gobbo BrazUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Departamento de Especialidades Cir..rgicas e Anestesiologia, Botucatu, SP, Brazil.
Norma Sueli Pinheiro M DoloUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Departamento de Especialidades Cir..rgicas e Anestesiologia, Botucatu, SP, Brazil.
Universidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe influence of different crystalloid solutions infused during deceased-donor kidney transplant on the incidence of delayed graft function remains unclear. We investigated the influence of Plasma-Lyte.½ vs. 0.9% saline on the incidence of delayed graft function in deceased-donor kidney transplant recipients.

methodsWe conducted a single-blind randomized controlled trial of 104 patients aged 18 to 65 years who underwent deceased-donor kidney transplant under general anesthesia. Patients were randomly assigned to receive either Plasma-Lyte.½ (n.ß=.ß52) or 0.9% saline (n.ß=.ß52), at the same infusion volume, for intraoperative fluid replacement. The primary outcome was the occurrence of delayed graft function. Secondary outcomes included metabolic and electrolytic changes at the end of surgery.

resultsTwo patients in the Plasma-Lyte.½ group and one in the 0.9% saline group died postoperatively and were not included for analysis. The incidence of delayed graft function in Plasma-Lyte.½ and 0.9% saline groups were 60.0% (95% Confidence Interval [95% CI 46.2...72.4]) and 74.5% (95% CI 61.1...84.4), respectively (p.ß=.ß0.140). Mean (standard deviation) values of immediate postoperative pH and serum chloride levels in Plasma-Lyte.½ and 0.9% saline groups were 7.306 (0.071) and 7.273 (0.061) (p.ß=.ß0.013), and 99.6 (4.2) mEq.L

conclusionIn deceased-donor kidney transplant recipients, the incidence of delayed graft function is not influenced by Plasma-Lyte.½ or 0.9% saline used for intraoperative fluid replacement.

Indexed as

Kidney TransplantationSaline SolutionDelayed Graft FunctionElectrolytesGluconatesHumansKidneyMagnesium ChloridePotassium ChlorideSingle-Blind MethodSodium AcetateSodium ChlorideElectrolytesGluconatesMagnesium ChloridePlasma-lyte 148Plasmalyte APotassium ChlorideSaline SolutionSodium AcetateSodium ChlorideAcid-base equilibriumAnesthesiaCrystalloid solutionsDelayed graft functionElectrolytesKidney transplantation

Identifiers

PMID34563559
PMCPMC9659989
OpenAlexW3202556126

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.