ArticleDental materials : official publication of the Academy of Dental Materials2021
Unveiling structure-activity relationships of proanthocyanidins with dentin collagen.
Article in Dental materials : official publication of the Academy of Dental Materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Effects of mussel-inspired compounds on dentin bonding: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Long-term nano-dynamic mechanical analysis and micro-permeability of adhesive interface components using four AB-type proanthocyanidin neutral primers.Journal of dentistry · 2026Article
- Advanced biomechanics and stability of the resin-dentin complex via modular A- and B-type proanthocyanidins.Biomaterials · 2026Article
- Polyphenol-functionalized silver nanoparticles promote differential remineralization and reinforcement of demineralized dentin.Journal of applied oral science : revista FOB · 2026Article
- A Bioinspired Approach to Mechanically Reinforce Collagen-Rich Tissues Using Modularly Defined Stilbenoids.Biopolymers · 2026Article
- Promoting collagen synthesis: a viable strategy to combat skin ageing.Journal of enzyme inhibition and medicinal chemistry · 2025Review
- Structure-activity relationships of A-and B-type proanthocyanidins in long-term dentin biomodification and biocompatibility.Journal of dentistry · 2025Article
- Biomineralization of dental tissues with natural drugs: a comprehensive review.The Saudi dental journal · 2025Review
- A dual action approach of B-type proanthocyanidins for silencing enzymatic activity and sealing natural caries-affected dentin-resin interfaces.Journal of dentistry · 2025Article
- Optimization of dental adhesive interfaces using tissue biomodulation with DESIGNER biopolymers.Dental materials : official publication of the Academy of Dental Materials · 2025Article
- Regulatory potency of oligomeric proanthocyanidins (PACs) on extrafibrillar and intrafibrillar collagen mineralization.Journal of applied polymer science · 2025Article
- Preparation, Modification, Quantitation, and Dentin Biomodification Activity of Selectively Enriched Proanthocyanidins.Journal of natural products · 2025Article
- Prodelphinidins enhance dentin matrix properties and promote adhesion to methacrylate resin.Dental materials : official publication of the Academy of Dental Materials · 2024Article
- Preliminary Evaluation of Bioactive Collagen-Polyphenol Surface Nanolayers on Titanium Implants: An X-ray Photoelectron Spectroscopy and Bone Implant Study.Journal of functional biomaterials · 2024Article
- Chemical Transformation of B- to A-type Proanthocyanidins and 3D Structural Implications.Journal of natural products · 2024Article
- From medical strategy to foodborne prophylactic strategy: Stabilizing dental collagen with aloin.Food science & nutrition · 2024Article
- Theaflavin -3,3'-digallate/ethanol: a novel cross-linker for stabilizing dentin collagen.Frontiers in bioengineering and biotechnology · 2024Article
- Modulatory role of terminal monomeric flavan-3-ol units in the viscoelasticity of dentin.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- Unprecedented Benzoquinone Motifs Reveal Post-Oligomerizational Modification of Proanthocyanidins.The Journal of organic chemistry · 2023Article
- B-type Proanthocyanidins with Dentin Biomodification Activity from Cocoa (Journal of agricultural and food chemistry · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo elucidate the structure-activity relationships (SARs) of proanthocyanidins (PACs) with type I collagen using sixteen chemically defined PACs with degree of polymerization (DP) 2-6.
methodsUnder a dentin model, the biomimicry of PACs with type I collagen was investigated by dynamic mechanical analysis (DMA) and infrared spectroscopy. The dentin matrix was modified with PACs from Pinus massoniana [monomers (Mon-1 and Mon-2), dimers (Dim-1-Dim-4), trimers (Tri-1-Tri-4), tetramers (Tet-1-Tet-5), and hexamer (Hex-1)]. A strain sweep method in a 3-point bending submersion clamp was used to assess the viscoelastic properties [storage (E'), loss (E"), and complex moduli (E*) and tan δ] of the dentin matrix before and after biomodification. Biochemical analysis of the dentin matrix was assessed with FTIR spectroscopy. Data were statistically analyzed using one-way ANOVA and post-hoc tests (α = 0.05).
resultsDP had a significant effect on modified dentin moduli (tetramers ≈ trimers > hexamers ≈ dimers > monomers ≈ control, p < 0.001). Trimers and tetramers yielded 6- to 8-fold increase in the mechanical properties of modified dentin and induced conformational changes to the secondary structure of collagen. Modifications to the tertiary structure of collagen was shown in all PAC modified-dentin matrices. SIGNIFICANCE: Findings establish three key SARs: (i) increasing DP generally enhances biomimicry potential of PACs in modulating the mechanical and chemical properties of dentin (ii) the secondary structure of dentin collagen is affected by the position of B-type inter-flavanyl linkages (4β → 6 and 4β → 8); and (iii) the terminal monomeric flavan-3-ol unit plays a modulatory role in the viscoelasticity of dentin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.