Evidence map›Paper›PMID 34563265›Full record

ArticleGenes and environment : the official journal of the Japanese Environmental Mutagen Society2021

MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis.

Xiaobo Dong, Jun Wang, Gesheng Wang, Jiayue Wang, Lei Wang, Yong Du

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Children (Basel, Switzerland) · 2025
    Review
  6. Article
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  9. Article
  10. Effects of Methylenetetrahydrofolate Reductase (Clinical ophthalmology (Auckland, N.Z.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiaobo Dong *The Third department of Encephalopathy, Dongfang Hospital Beijing University of Chinese Medicine, No. 6, Area 1, Fangxing Garden Fangzhuang, Fengtai District, Beijing, 100078, China.
Jun Wang *Department of Neurology, Chinese PLA General Hospital, Beijing, 100039, China.
Gesheng WangThe Third department of Encephalopathy, Dongfang Hospital Beijing University of Chinese Medicine, No. 6, Area 1, Fangxing Garden Fangzhuang, Fengtai District, Beijing, 100078, China. wanggesheng0623@163.com.
Jiayue WangThe Third department of Encephalopathy, Dongfang Hospital Beijing University of Chinese Medicine, No. 6, Area 1, Fangxing Garden Fangzhuang, Fengtai District, Beijing, 100078, China.
Lei WangThe Third department of Encephalopathy, Dongfang Hospital Beijing University of Chinese Medicine, No. 6, Area 1, Fangxing Garden Fangzhuang, Fengtai District, Beijing, 100078, China.
Yong DuThe Third department of Encephalopathy, Dongfang Hospital Beijing University of Chinese Medicine, No. 6, Area 1, Fangxing Garden Fangzhuang, Fengtai District, Beijing, 100078, China.
Beijing University of Chinese Medicine · CNChinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have shown the effect of MTHFR A1298C gene polymorphism on stroke risk. But the results of published studies remained inconclusive and controversial. So we conducted a meta-analysis to accurately estimate the potential association between MTHFR A1298C gene polymorphism and stroke susceptibility.

methodsA systematic literature search on Embase, Pubmed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) and WanFang electronic database identified 40 articles including 5725 cases and 8655 controls. Strength of association was evaluated by pooled odds ratio (OR), 95% confidence interval (CI) and p value. Funnel plots and Begger's regression test were applied for testing the publication bias. Statistical analysis of all data was performed by Stata 12.0.

resultsThe meta-analysis results indicated a significant relationship between MTHFR gene A1298C polymorphisms and stoke risk under the C allelic genetic model (OR = 1.19, 95%CI = 1.07-1.32, p = 0.001), dominant genetic model (OR = 1.19, 95%CI = 1.06-1.33, p = 0.004) and recessive genetic model (OR = 1.43, 95%CI =1.15-1.77, p = 0.001). In subgroup analysis, we discovered obvious correlation in three genetic model of Asian, stroke type, adult by ethnicity, population, stroke type, source of control and case size. Additionally, in studies of control from hospital and case size equal 100, obvious correlation was also found in the three genetic model.

conclusionsOur meta-analysis results indicated that there was evidence to support the correlation between MTHFR A1298C polymorphism and stroke susceptibility, especially in adults and ischemic stroke.

Indexed as

Meta-analysisMTHFR A1298CPolymorphismStroke

Identifiers

PMID34563265
PMCPMC8467014
OpenAlexW3201753228

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.