ArticleAlzheimer's research & therapy2021
The circadian rest-activity pattern predicts cognitive decline among mild-moderate Alzheimer's disease patients.
Article in Alzheimer's research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- AI and Wearables for Early Detection of Cognitive Impairment and Dementia: Systematic Review.Journal of medical Internet research · 2026Pooled it
- Characterizing circadian rest-activity rhythm patterns across Alzheimer's disease continuum in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- AI-enabled digital phenotyping for Alzheimer's disease: a review of multimodal sensor integration and symptom trajectories.Alzheimer's research & therapy · 2026Review
- Exercise and neural circuit stability in early Alzheimer's disease: evidence across memory, executive, cholinergic, and circadian systems.Frontiers in aging neuroscience · 2026Review
- Sleep Rhythmicity as a Core Domain of Multidimensional Sleep Health Associated with Cognitive Impairment in Older Men.Nature and science of sleep · 2026Article
- Beyond FITT: addressing density in understanding the dose-response relationships of physical activity with health-an example based on brain health.European journal of applied physiology · 2025Review
- Article
- Predicting Social Frailty in Older Adults Using Fitbit-Derived Circadian and Heart Rate Biomarkers: Cross-Sectional Study.JMIR formative research · 2025Article
- An exploratory pilot study on social rhythm regularity, and its associations with sleep, circadian, affective, and alcohol use outcomes in late adolescents.Journal of sleep research · 2025Article
- Article
- Sex differences in the relationships between 24-h rest-activity patterns and plasma markers of Alzheimer's disease pathology.Alzheimer's research & therapy · 2024Article
- Digital biomarkers for non-motor symptoms in Parkinson's disease: the state of the art.NPJ digital medicine · 2024Review
- Associations of 24-Hour Rest-Activity Rhythm Fragmentation, Cognitive Decline, and Postmortem Locus Coeruleus Hypopigmentation in Alzheimer's Disease.Annals of neurology · 2024Article
- Circadian Rhythm Changes in Healthy Aging and Mild Cognitive Impairment.Advanced biology · 2023Review
- Review
- Abnormalities of Rest-Activity and Light Exposure Rhythms Associated with Cognitive Function in Patients with Mild Cognitive Impairment (MCI).Journal of circadian rhythms · 2023Article
- Blunted rest-activity circadian rhythm increases the risk of all-cause, cardiovascular disease and cancer mortality in US adults.Scientific reports · 2022Article
- Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer's Disease.Frontiers in aging neuroscience · 2022Article
- Brain Structural and Functional Changes in Cognitive Impairment Due to Alzheimer's Disease.Frontiers in psychology · 2022Review
- Rest-activity rhythm characteristics associated with lower cognitive performance and Alzheimer's disease biomarkers in midlife women.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlterations in circadian rhythms are present in the presymptomatic stage of Alzheimer's disease (AD), possibly contributing to its pathogenesis. However, it is unknown whether such alterations are associated with worse outcomes once individuals are diagnosed with symptomatic disease. We aimed to evaluate the association between the circadian rest-activity pattern and AD-related features in patients with mild-moderate AD.
methodsWe assessed the circadian rest-activity pattern of consecutive patients with mild-moderate AD through actigraphy for 14 days. Cerebrospinal fluid was obtained to determine the levels of important pathological markers including amyloid-beta protein (Aβ42), phosphorylated tau (P-tau), total tau (T-tau), and neurofilament light (NF-L). Neuropsychological evaluation was conducted at the beginning of the study and after 12 months of follow-up. Linear regression models were performed considering the global population and Aβ42+ patients only.
resultsThe cohort included 100 patients with mild-moderate AD. The median age [p
conclusionsOur results suggest a potential role of the circadian rest-activity pattern in predicting the cognitive decline of patients with mild-moderate AD. Further studies are warranted to confirm these findings and to elucidate whether there is causality among the observed associations.
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