ArticleBMC public health2021
Performance of existing and novel surveillance case definitions for COVID-19 in household contacts of PCR-confirmed COVID-19.
Article in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Vaccination and hybrid immunity is associated with SARS-CoV-2 protection but not shedding duration in rural Guatemalan households.Research square · 2026Article
- Comparison between Saliva and Nasopharyngeal Swabs for the Rapid Detection of Respiratory Viruses Using the Roche Cobas® Liat® Polymerase Chain Reaction System in Rural Guatemala.The American journal of tropical medicine and hygiene · 2025Article
- A Comparative Analysis of Universal and Sentinel Surveillance Data for Coronavirus Disease 2019: Insights From Argentina, Chile, and Mexico (2020-2022).The Journal of infectious diseases · 2025Article
- Use of Telehealth Information for Early Detection: Insights From the COVID-19 Pandemic.American journal of public health · 2024Observational
- Clinical and Economic Impact of COVID-19 on Agricultural Workers, GuatemalaEmerging infectious diseases · 2022Review
- Comparison of longitudinal trends in self-reported symptoms and COVID-19 case activity in Ontario, Canada.PloS one · 2022Article
- Research on the Epidemiology of SARS-CoV-2 in Essential Response Personnel (RECOVER): Protocol for a Multisite Longitudinal Cohort Study.JMIR research protocols · 2021Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOptimized symptom-based COVID-19 case definitions that guide public health surveillance and individual patient management in the community may assist pandemic control.
methodsWe assessed diagnostic performance of existing cases definitions (e.g. influenza-like illness, COVID-like illness) using symptoms reported from 185 household contacts to a PCR-confirmed case of COVID-19 in Wisconsin and Utah, United States. We stratified analyses between adults and children. We also constructed novel case definitions for comparison.
resultsExisting COVID-19 case definitions generally showed high sensitivity (86-96%) but low positive predictive value (PPV) (36-49%; F-1 score 52-63) in this community cohort. Top performing novel symptom combinations included taste or smell dysfunction and improved the balance of sensitivity and PPV (F-1 score 78-80). Performance indicators were generally lower for children (< 18 years of age).
conclusionsExisting COVID-19 case definitions appropriately screened in household contacts with COVID-19. Novel symptom combinations incorporating taste or smell dysfunction as a primary component improved accuracy. Case definitions tailored for children versus adults should be further explored.
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