Observational studyBMC cardiovascular disorders2021
Admission white blood cell count predicts post-discharge mortality in patients with acute aortic dissection: data from the MIMIC-III database.
Observational study in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Prognostic value of initial hematoma area in patients with acute type B aortic intramural hematoma.Quantitative imaging in medicine and surgery · 2026Article
- Predictive value of initial triage vital signs for in-hospital mortality in acute aortic dissection patients: a retrospective study in the emergency department.Frontiers in medicine · 2026Article
- Evaluation of the effectiveness of a digital-intelligent-system-based implementation strategy in improving the quality of prehospital medical care: rationale and design of a stepped-wedge cluster randomized controlled trial.BMC health services research · 2025Article
- Predictive Value of the White Blood Cells Count for the Prognosis of Hospitalized Patients with Acute Aortic Dissection.Reviews in cardiovascular medicine · 2025Article
- Platelet-to-white blood cell ratio as a predictor of postoperative outcomes in acute type A aortic dissection: a single-center retrospective analysis.Frontiers in cardiovascular medicine · 2025Article
- Salp swarm-optimized machine learning models for predicting preoperative aortic rupture risk in acute type a aortic dissection patients.Frontiers in physiology · 2025Article
- Inflammatory Trajectory and Anti-Inflammatory Pharmacotherapy in Frozen Elephant Trunk-Treated Acute Type I Aortic Dissection.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Article
- Short- and Long-term survival prediction in patients with acute type A aortic dissection undergoing open surgery.Journal of cardiothoracic surgery · 2024Article
- Perioperative Risk Factors for Post-operative Pneumonia after Type A Acute Aortic Dissection Surgery.Current medical science · 2023Article
- Prediction of in-hospital death following acute type A aortic dissection.Frontiers in public health · 2023Article
- Development and validation of a machine-learning model for prediction of hypoxemia after extubation in intensive care units.Annals of translational medicine · 2022Article
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7 authors.
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Abstract
backgroundInflammation underlies both the pathogenesis and prognosis in patients with acute aortic dissection (AAD). This study aimed to assess the association of ICU admission of white blood cell count (WBCc) with post-discharge mortality in these patients.
methodsClinical data were extracted from the MIMIC-III V1.4 database. After adjusted to covariables, Cox regression analysis and Kaplan-Meier survival curve were performed to determine the relationship between WBCc on admission and post-discharge mortality (30-day, 90-day, 1-year and 5-year) in AAD patients. Subgroup analysis and receiver operating characteristic (ROC) curve analysis were used to test the performance of WBCc in predicting mortality in AAD patients.
resultsA total of 325 eligible patients were divided into 2 groups: normal-WBCc group (≤ 11 k/uL) and high-WBCc group (> 11 K/uL). In univariate Cox regression analysis, high WBCc was significant risk predictor of 30-day, 90-day, 1-year and 5-year mortality [hazard ratio (HR), 95% CI, P 2.58 1.36-4.91 0.004; 3.16 1.76-5.70 0.000; 2.74 1.57-4.79 0.000; 2.10 1.23-3.54 0.006]. After adjusting for age and other risks, high WBCc remained a significant predictor of 30-day, 90-day and 1-year mortality in AAD patients (HR, 95% CI, P 1.994 1.058-3.76 0.033; 2.118 1.175-3.819 0.013; 2.37 1.343-4.181 0.003). The area under ROC curve of WBCc for predicting 30-day, 90-day, 1-year and 5-year mortality were 0.69, 0.70, 0.66 and 0.61, respectively. The results from subgroups analysis showed that there was no interaction in most strata and patients who were younger than 69 years of age or had history of respiratory disease with an elevated WBCc had an excess risk of 30-day mortality (HR, 95% CI, P 3.18 1.41-7.14 0.005; 3.84 1.05-14.13 0.043).
conclusionsHigher than normal WBCc on admission may predict post-discharge mortality in patients with AAD.
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