Evidence map›Paper›PMID 34563046›Full record

ArticleCurrent issues in molecular biology2021

Hemopexin Modulates Expression of Complement Regulatory Proteins in Rat Glomeruli.

Maria G Detsika, Elias A Lianos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Maria G Detsika1st Department of Critical Care Medicine and Pulmonary Services, G. P. Livanou and M. Simou Laboratories, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10675 Athens, Greece.
Elias A LianosVeterans Affairs Medical Center and Virginia Tech., Carilion School of Medicine, 1970 Roanoke Blvd, Salem, VA 24153, USA.
Evangelismos Hospital · GRVirginia Tech · US

Funding

BLRD VA I01 BX004333This study was co-financed by European Union (European Social Fund) and Greek national funds through the Operational Program 'Education and Lifelong Learning' of the National Strategic Reference Framework - Research Funding Program: Aristeia I to E.A.L. NA
6 · The paper itself

Abstract

In systemic hemolysis and in hematuric forms of kidney injury, the major heme scavenging protein, hemopexin (HPX), becomes depleted, and the glomerular microvasculature (glomeruli) is exposed to high concentrations of unbound heme, which, in addition to causing oxidative injury, can activate complement cascades; thus, compounding extent of injury. It is unknown whether unbound heme can also activate specific complement regulatory proteins that could defend against complement-dependent injury. Isolated rat glomeruli were incubated in media supplemented with HPX-deficient (HPX

Indexed as

Complement ActivationAnimalsAntigens, SurfaceCD55 AntigensHemopexinRatsReceptors, Cell SurfaceAntigens, SurfaceCD55 AntigensCr1l protein, ratHemopexinReceptors, Cell SurfaceCD59complementCrrydecay accelerating factor (DAF)heminhemopexin

Identifiers

PMID34563046
PMCPMC8928991
OpenAlexW3198647963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.