Evidence map›Paper›PMID 34562949›Full record

ArticleBioengineering (Basel, Switzerland)2021

Thermo-Responsive Hydrogel-Based Soft Valves with Annular Actuation Calibration and Circumferential Gripping.

Manivannan Sivaperuman Kalairaj, Hritwick Banerjee, Kirthika Senthil Kumar, Keith Gerard Lopez, Hongliang Ren

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Manivannan Sivaperuman KalairajDepartment of Biomedical Engineering, National University of Singapore, Singapore 117575, Singapore.ORCID 0000-0002-3218-7135
Hritwick BanerjeeDepartment of Biomedical Engineering, National University of Singapore, Singapore 117575, Singapore.ORCID 0000-0003-2939-646X
Kirthika Senthil KumarDepartment of Biomedical Engineering, National University of Singapore, Singapore 117575, Singapore.ORCID 0000-0002-6412-5879
Keith Gerard LopezDepartment of Biomedical Engineering, National University of Singapore, Singapore 117575, Singapore.
Hongliang RenDepartment of Biomedical Engineering, National University of Singapore, Singapore 117575, Singapore.ORCID 0000-0002-6488-1551

Funding

Ministry of Education - Singapore R-397-000-353-114Ministry of Science and Technology of the People's Republic of China 2018YFB1307703National Key Research and Development Program of China 2018YFB1307703
6 · The paper itself

Abstract

Valves are largely useful for treatment assistance devices, e.g., supporting fluid circulation movement in the human body. However, the valves presently used in biomedical applications still use materials that are rigid, non-compliant, and hard to integrate with human tissues. Here, we propose biologically-inspired, stimuli-responsive valves and evaluate N-Isopropylacrylamide hydrogels-based valve (NPHV) and PAAm-alginate hydrogels-based valve (PAHV) performances with different chemical syntheses for optimizing better valve action. Once heated at 40 ∘C, the NPHV outperforms the PAHV in annular actuation (NPHV: 1.93 mm displacement in 4 min; PAHV: 0.8 mm displacement in 30 min). In contrast, the PAHV exhibits a flow rate change of up to 20%, and a payload of 100% when the object is at 100 ∘C. The PAHV demonstrated a completely soft, stretchable circular gripper with a high load-to-weight ratio for diversified applications. These valves are fabricated with a simple one-pot method that, once further optimized, can offer transdisciplinary applications.

Indexed as

hydrogelssoft actuatorssoft gripperthermo-responsive polymersvalves

Identifiers

PMID34562949
PMCPMC8468597

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.