Evidence map›Paper›PMID 34562939›Full record

ArticleBioengineering (Basel, Switzerland)2021

Machine Learning Prediction Models for Mitral Valve Repairability and Mitral Regurgitation Recurrence in Patients Undergoing Surgical Mitral Valve Repair.

Marco Penso, Mauro Pepi, Valentina Mantegazza, Claudia Cefalù, Manuela Muratori, Laura Fusini, Paola Gripari, Sarah Ghulam Ali, Enrico G Caiani, Gloria Tamborini

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Echocardiographic Assessment of Patients Undergoing Mitral Valve Repair.Journal of cardiovascular development and disease · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. 3D echocardiography in mitral valve prolapse.Frontiers in cardiovascular medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marco PensoDepartment of Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.ORCID 0000-0003-4040-6112
Mauro PepiDepartment of Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.
Valentina MantegazzaDepartment of Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.ORCID 0000-0002-0696-1625
Claudia CefalùDepartment of Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.
Manuela MuratoriDepartment of Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.
Laura FusiniDepartment of Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.ORCID 0000-0003-0309-6231
Paola GripariDepartment of Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.
Sarah Ghulam AliDepartment of Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.
Enrico G CaianiDepartment of Electronics, Information and Biomedical Engineering, Politecnico di Milano, 20133 Milan, Italy.ORCID 0000-0002-1770-6486
Gloria TamboriniDepartment of Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMitral valve regurgitation (MR) is the most common valvular heart disease and current variables associated with MR recurrence are still controversial. We aim to develop a machine learning-based prognostic model to predict causes of mitral valve (MV) repair failure and MR recurrence.

methods1000 patients who underwent MV repair at our institution between 2008 and 2018 were enrolled. Patients were followed longitudinally for up to three years. Clinical and echocardiographic data were included in the analysis. Endpoints were MV repair surgical failure with consequent MV replacement or moderate/severe MR (>2+) recurrence at one-month and moderate/severe MR recurrence after three years.

results817 patients (DS1) had an echocardiographic examination at one-month while 295 (DS2) also had one at three years. Data were randomly divided into training (DS1: n = 654; DS2: n = 206) and validation (DS1: n = 164; DS2 n = 89) cohorts. For intra-operative or early MV repair failure assessment, the best area under the curve (AUC) was 0.75 and the complexity of mitral valve prolapse was the main predictor. In predicting moderate/severe recurrent MR at three years, the best AUC was 0.92 and residual MR at six months was the most important predictor.

conclusionsMachine learning algorithms may improve prognosis after MV repair procedure, thus improving indications for correct candidate selection for MV surgical repair.

Indexed as

heartmachine learningmitral valve prolapsemitral valve repairprediction modelprimary mitral regurgitation

Identifiers

PMID34562939
PMCPMC8469985

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.