Evidence map›Paper›PMID 34562910›Full record

ArticleBiosensors2021

A Variable Height Microfluidic Device for Multiplexed Immunoassay Analysis of Traumatic Brain Injury Biomarkers.

Alyse D Krausz, Frederick K Korley, Mark A Burns

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alyse D KrauszBiomedical Engineering Department, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8045-1623
Frederick K KorleyDepartment of Emergency Medicine and Michigan Medicle, University of Michigan, Ann Arbor, MI 48109, USA.
Mark A BurnsBiomedical Engineering Department, University of Michigan, Ann Arbor, MI 48109, USA.

Funding

Microfluidics in Biomedical Sciences Training ProgramT32EB005582 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FAN, XUDONG · 2005 to 2020
$3.9M
Joyce and Don Massey Family Foundation N/ANIBIB NIH HHS T32 EB005582University of Michigan Precision Health Scholars Awards N/A
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a leading cause of global morbidity and mortality, partially due to the lack of sensitive diagnostic methods and efficacious therapies. Panels of protein biomarkers have been proposed as a way of diagnosing and monitoring TBI. To measure multiple TBI biomarkers simultaneously, we present a variable height microfluidic device consisting of a single channel that varies in height between the inlet and outlet and can passively multiplex bead-based immunoassays by trapping assay beads at the point where their diameter matches the channel height. We developed bead-based quantum dot-linked immunosorbent assays (QLISAs) for interleukin-6 (IL-6), glial fibrillary acidic protein (GFAP), and interleukin-8 (IL-8) using Dynabeads

Indexed as

ImmunoassayBiomarkersBrain Injuries, TraumaticGlial Fibrillary Acidic ProteinHumansLab-On-A-Chip DevicesMicrofluidic Analytical TechniquesBiomarkersGlial Fibrillary Acidic Proteinbiomarkersimmunoassaymicrofluidicsmultiplextraumatic brain injury

Identifiers

PMID34562910
PMCPMC8472232

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.