Evidence map›Paper›PMID 34562896›Full record

ArticleBiosensors2021

A Smart Core-Crosslinked Supramolecular Drug Delivery System (SDDS) Enabled by Pendant Cyclodextrins Encapsulation of Drug Dimers via Host-Guest Interaction.

Xin Xing, Zhijun Guo, Yue Su, Zhen Yang, Jiwen Qian, Chunlai Tu, Lijuan Zhu, Feng Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xin XingDepartment of Pharmacy and Central Laboratory, Fengxian Hospital, Southern Medical University, 6600 Nanfeng Road, Shanghai 201499, China.
Zhijun GuoDepartment of Pharmacy and Central Laboratory, Fengxian Hospital, Southern Medical University, 6600 Nanfeng Road, Shanghai 201499, China.
Yue SuFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Zhen YangDepartment of Pharmacy and Central Laboratory, Fengxian Hospital, Southern Medical University, 6600 Nanfeng Road, Shanghai 201499, China.
Jiwen QianFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Chunlai TuFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Lijuan ZhuFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.ORCID 0000-0002-1409-7443
Feng XuDepartment of Pharmacy and Central Laboratory, Fengxian Hospital, Southern Medical University, 6600 Nanfeng Road, Shanghai 201499, China.ORCID 0000-0001-6215-8696
Shanghai Jiao Tong University · CNSouthern Medical University · CN

Funding

National Natural Science Foundation of China 21805129National Natural Science Foundation of China 21875134Shanghai Fengxian District Science and Technology Commission Project 20181802Shanghai Municipal Health Commission 201940506
6 · The paper itself

Abstract

Owing to poor aqueous solubility and low delivery efficiency, most of anti-cancer chemodrugs depend on various smart drug delivery platforms to enhance the treatment efficacy. Herein, a stimuli-responsive supramolecular drug delivery system (SDDS) is developed based on polymeric cyclodextrins (PCD) which crosslinked by stimuli-cleavable drug dimers via host-guest interaction. PEGylated PCD was precisely controlled synthesized by ring-opening polymerization and azide-alkyne click chemistry, and two doxorubicins (DOX) were linked with a disulfide bond to form a drug dimer (ss-DOX). They then co-assembled into supramolecular micelles. Drug dimers were utilized as cross-linkers to stabilize the micelles. The drug loading efficiency was very high that could be up to 98%. The size and morphology were measured by DLS and TEM. Owing to the disulfide bonds of drug dimers, these supramolecular micelles were dissociated by treating with dithiothreitol (DTT). In the meanwhile, the free DOXs were recovered and released from cavities of cyclodextrins because of dynamic equilibrium and hydrophilicity changes. The release profile was studied under mimic physiological conditions. Furthermore, in vitro cytotoxicity study showed excellent anti-cancer efficacy of reduced-responsive supramolecular polymeric micelles. Therefore, it can be served as a safe and stimuli-responsive SDDS for cancer therapy.

Indexed as

CyclodextrinsMicellesDapsoneDisulfidesDrug Delivery SystemsPolymersCyclodextrinsDapsoneDisulfidesMicellesPolymersSDDScore-crosslinked micellescyclodextrin-based polymerdrug dimerstimuli-responsivesupramolecular drug delivery system

Identifiers

PMID34562896
PMCPMC8466753
OpenAlexW3196410749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.