ArticleBrain stimulation
Multi-scale modeling toolbox for single neuron and subcellular activity under Transcranial Magnetic Stimulation.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Transcranial direct current stimulation for gait recovery following stroke: A systematic review of current literature and beyond.Frontiers in neurology · 2022Pooled it
- Mechanisms of transcranial magnetic brain stimulation.Physiological reviews · 2026Review
- When control isn't controlled: How different experimental sham control conditions complicate TMS evidence in addiction.Drug and alcohol dependence reports · 2026Article
- Cellular Mechanisms of Transcranial Magnetic Stimulation in Climbing Fibers and Purkinje Neurons in the Cerebellum.bioRxiv : the preprint server for biology · 2026Article
- Neuromodulation and rehabilitation of post-stroke cognitive impairment: challenges and prospects.Frontiers in psychiatry · 2026Review
- Multi-scale modelling of location- and frequency-dependent synaptic plasticity induced by repetitive magnetic stimulation in the dendrites of pyramidal neurons.PLoS computational biology · 2025Article
- Simulation of evoked responses to transcranial magnetic stimulation using a multiscale cortical circuit model.bioRxiv : the preprint server for biology · 2025Article
- Statistical method accounts for microscopic electric field distortions around neurons when simulating activation thresholds.bioRxiv : the preprint server for biology · 2025Article
- Next generation bioelectronic medicine: making the case for non-invasive closed-loop autonomic neuromodulation.Bioelectronic medicine · 2025Review
- Low-Frequency (1 Hz) Repetitive Trans-Spinal Magnetic Stimulation Attenuates NLRP3-Driven Neuroinflammation and Enhances Motor Recovery in Spinal Cord-Injured Mice.Journal of inflammation research · 2025Article
- Circuits and mechanisms for TMS-induced corticospinal waves: Connecting sensitivity analysis to the network graph.PLoS computational biology · 2024Article
- Multi-scale modeling to investigate the effects of transcranial magnetic stimulation on morphologically-realistic neuron with depression.Cognitive neurodynamics · 2024Article
- A survey on integral equations for bioelectric modeling.Physics in medicine and biology · 2024Review
- Ultra-high frequency repetitive TMS at subthreshold intensity induces suprathreshold motor response via temporal summation.Journal of neural engineering · 2024Article
- A New Angle on Transcranial Magnetic Stimulation Coil Orientation: A Targeted Narrative Review.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Review
- Induced neural phase precession through exogenous electric fields.Nature communications · 2024Article
- Electric-field-based dosing for TMS.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Axon morphology and intrinsic cellular properties determine repetitive transcranial magnetic stimulation threshold for plasticity.Frontiers in cellular neuroscience · 2024Article
- Estimations of Charge Deposition Onto Convoluted Axon Surfaces Within Extracellular Electric Fields.IEEE transactions on bio-medical engineering · 2024Article
- Repetitive transcranial magnetic stimulation (rTMS) triggers dose-dependent homeostatic rewiring in recurrent neuronal networks.PLoS computational biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundTranscranial Magnetic Stimulation (TMS) is a widely used non-invasive brain stimulation method. However, its mechanism of action and the neural response to TMS are still poorly understood. Multi-scale modeling can complement experimental research to study the subcellular neural effects of TMS. At the macroscopic level, sophisticated numerical models exist to estimate the induced electric fields. However, multi-scale computational modeling approaches to predict TMS cellular and subcellular responses, crucial to understanding TMS plasticity inducing protocols, are not available so far.
objectiveWe develop an open-source multi-scale toolbox Neuron Modeling for TMS (NeMo-TMS) to address this problem.
methodsNeMo-TMS generates accurate neuron models from morphological reconstructions, couples them to the external electric fields induced by TMS, and simulates the cellular and subcellular responses of single-pulse and repetitive TMS.
resultsWe provide examples showing some of the capabilities of the toolbox.
conclusionNeMo-TMS toolbox allows researchers a previously not available level of detail and precision in realistically modeling the physical and physiological effects of TMS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.