Evidence map›Paper›PMID 34562531›Full record

ArticleAppetite2022

Stress-induced alterations in HPA-axis reactivity and mesolimbic reward activation in individuals with emotional eating.

Rose Seoyoung Chang, Hilâl Cerit, Taryn Hye, E Leighton Durham, Harlyn Aizley, Sarah Boukezzi, Florina Haimovici, Jill M Goldstein, Daniel G Dillon, Diego A Pizzagalli and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Appetite, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Rose Seoyoung ChangDivision of Women's Health, Department of Medicine; 75 Francis St., Boston, MA, 02115, USA.
Hilâl CeritDivision of Women's Health, Department of Medicine; 75 Francis St., Boston, MA, 02115, USA; Harvard Medical School, 25 Shattuck St., Boston, MA, 02115, USA.
Taryn HyeDivision of Women's Health, Department of Medicine; 75 Francis St., Boston, MA, 02115, USA.
E Leighton DurhamDivision of Women's Health, Department of Medicine; 75 Francis St., Boston, MA, 02115, USA.
Harlyn AizleyDepartment of Psychiatry; 55 Fruit St., Boston, MA, 02114, USA.
Sarah BoukezziDivision of Women's Health, Department of Medicine; 75 Francis St., Boston, MA, 02115, USA; Harvard Medical School, 25 Shattuck St., Boston, MA, 02115, USA.
Florina HaimoviciDepartment of Psychiatry; Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA; Harvard Medical School, 25 Shattuck St., Boston, MA, 02115, USA.
Jill M GoldsteinDivision of Women's Health, Department of Medicine; 75 Francis St., Boston, MA, 02115, USA; Harvard Medical School, 25 Shattuck St., Boston, MA, 02115, USA; Department of Psychiatry; 55 Fruit St., Boston, MA, 02114, USA; Department of Obstetrics and Gynecology; 55 Fruit St., Boston, MA, 02114, USA; Innovation Center on Sex Differences in Medicine; Massachusetts General Hospital, 55 Fruit St., Boston, MA, 02114, USA.
Daniel G DillonHarvard Medical School, 25 Shattuck St., Boston, MA, 02115, USA; Center for Depression, Anxiety and Stress Research; 115 Mill St., Belmont, MA, 02478, USA.
Diego A PizzagalliHarvard Medical School, 25 Shattuck St., Boston, MA, 02115, USA; Center for Depression, Anxiety and Stress Research; 115 Mill St., Belmont, MA, 02478, USA; McLean Imaging Center; McLean Hospital, 115 Mill St., Belmont, MA, 02478, USA.
Laura M HolsenDivision of Women's Health, Department of Medicine; 75 Francis St., Boston, MA, 02115, USA; Department of Psychiatry; Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA; Harvard Medical School, 25 Shattuck St., Boston, MA, 02115, USA; Innovation Center on Sex Differences in Medicine; Massachusetts General Hospital, 55 Fruit St., Boston, MA, 02114, USA. Electronic address: lholsen@bwh.harvard.edu.
Harvard University · USSt. Francis College · USBrigham and Women's Hospital · USFruit Research Institute · CN

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Ghrelin Modulation of Mesolimbic Reward Signaling in Stress-induced HyperphagiaR01DK104772 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HOLSEN, LAURA MCGRATH · 2016 to 2020
$2.7M
NCATS NIH HHS UL1 TR001102NCATS NIH HHS UL1 TR002541NIDDK NIH HHS R01 DK104772
6 · The paper itself

Abstract

backgroundEmotional eating has emerged as a contributing factor to overeating, potentially leading to obesity or disordered eating behaviors. However, the underlying biological mechanisms related to emotional eating remain unclear. The present study examined emotional, hormonal, and neural alterations elicited by an acute laboratory stressor in individuals with and without emotional eating.

methodsEmotional (n = 13) and non-emotional eaters (n = 15) completed two main study visits, one week apart: one visit included a Stress version and the other a No-stress version of the Maastricht Acute Stress Task (MAST). Immediately pre- and post-MAST, blood was drawn for serum cortisol and participants rated their anxiety level. After the MAST, participants completed a Food Incentive Delay (FID) task during functional magnetic resonance imaging (fMRI), followed by an ad libitum snack period.

resultsEmotional eaters exhibited elevated anxiety (p = 0.037) and cortisol (p = 0.001) in response to the Stress MAST. There were no changes in anxiety or cortisol among non-emotional eaters in response to the Stress MAST or in either group in response to the No-stress MAST. In response to the Stress MAST, emotional eaters exhibited reduced activation during anticipation of food reward in mesolimbic reward regions (caudate: p = 0.014, nucleus accumbens: p = 0.022, putamen: p = 0.013), compared to non-emotional eaters. Groups did not differ in snack consumption.

conclusionsThese data indicate disrupted neuroendocrine and neural responsivity to psychosocial stress amongst otherwise-healthy emotional eaters, who demonstrated hyperactive HPA-axis response coupled with hypoactivation in reward circuitry. Differential responsivity to stress may represent a risk factor in the development of maladaptive eating behaviors.

Indexed as

Feeding BehaviorStress, PsychologicalEatingEmotionsHumansHydrocortisoneMagnetic Resonance ImagingRewardHydrocortisoneCortisolEating behaviorsEmotional eatingfMRIFood rewardStress

Identifiers

PMID34562531
PMCPMC8671188
OpenAlexW3200948427

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.