Evidence map›Paper›PMID 34562525›Full record

Observational studyAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2022

Serum Level of Polyubiquitinated PTEN and Loss of Kidney Function in American Indians With Type 2 Diabetes.

Helen C Looker, Chunru Lin, Viji Nair, Matthias Kretzler, Michael Mauer, Behzad Najafian, Robert G Nelson

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Helen C LookerChronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona. Electronic address: helen.looker@nih.gov.
Chunru LinDepartment of Molecular and Cellular Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas.
Viji NairComputational Medicine and Bioinformatics, Medical School, University of Michigan, Ann Arbor, Michigan.
Matthias KretzlerComputational Medicine and Bioinformatics, Medical School, University of Michigan, Ann Arbor, Michigan.
Michael MauerDepartment of Pediatrics, School of Medicine, University of Minnesota, Minneapolis, Minnesota.
Behzad NajafianDepartment of Laboratory Medicine and Pathology, UW Medicine, University of Washington, Seattle, Washington.
Robert G NelsonChronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona.
National Institute of Diabetes and Digestive and Kidney Diseases · USUniversity of Michigan–Ann Arbor · USThe University of Texas MD Anderson Cancer Center · USUniversity of Minnesota · USUniversity of Washington · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Epidemiology, Pathophysiology and Treatment of Diabetic NephropathyZIADK069062 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI NELSON, ROBERT G · 2009 to 2023
$10.1M
Intramural NIH HHS ZIA DK069062NIDDK NIH HHS P30 DK020572
6 · The paper itself

Abstract

RATIONALE &

objectiveFibrosis is a major driver of chronic kidney disease, and epithelial-mesenchymal transition (EMT) may contribute to its development. A polyubiquitinated form of phosphatase and tensin homolog (PTEN STUDY

designObservational cohort study. SETTING &

participantsSouthwest United States, American Indians (154 women, 80 men) with or at high risk for diabetic kidney disease (DKD). PREDICTORS: Serum level of PTEN OUTCOME: ≥40% loss of glomerular filtration rate (GFR) or onset of kidney failure. Kidney structural measures in a subset of study participants who underwent research kidney biopsies (n = 77). ANALYTICAL APPROACH: Cox proportional hazards models adjusted for age, sex, diabetes duration, hemoglobin A

resultsAt baseline, the participants' mean age was 42.8 ± 10.5 (SD) years, diabetes duration 11.5 ± 7.1 years, mean arterial pressure 90.5 ± 9.5 mm Hg, HbA LIMITATIONS: Small study in single population.

conclusionsHigher serum PTEN

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesAdultAlbuminuriaAmerican Indian or Alaska NativeDisease ProgressionFemaleGlomerular Filtration RateHumansKidneyMaleMiddle AgedPTEN PhosphohydrolaseRisk FactorsPTEN PhosphohydrolasePTEN protein, humanAlbuminuriabiomarkerdiabetic kidney disease (DKD)epithelial-mesenchymal transition (EMT)estimated glomerular filtration rate (eGFR)fibrosiskidney disease progressionkidney failurekidney lesionsPTENrenal function

Identifiers

PMID34562525
PMCPMC9740738
OpenAlexW3198948536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.