SynthesisEnvironmental research2022
DNA methylation changes associated with prenatal mercury exposure: A meta-analysis of prospective cohort studies from PACE consortium.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Environmental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
What it found
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Environment and CVD: moving from Risk Prediction to Risk Management.Current atherosclerosis reports · 2026Review
- The fetal exposome: cellular and epigenetic programming of neonatal immune function.Frontiers in immunology · 2026Review
- Metal Mixture Inflammatory Index and diabetes risk in US adults: a cross-sectional analysis of NHANES 1999-2020 and development of a LASSO-based prediction model.BMJ open diabetes research & care · 2025Article
- High exposure variance enables candidate biomarker detection in a small EWAS of methylmercury-exposed Peruvian adults.BMC genomic data · 2025Article
- Effects of Environmental Non-Essential Toxic Heavy Metals on Epigenetics During Development.Toxics · 2025Review
- Maternal Nutrition, Toxicants, and Epigenetic Programming of Obesity Across Generations.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Review
- Decoding the Epigenetics of Infertility: Mechanisms, Environmental Influences, and Therapeutic Strategies.Epigenomes · 2024Review
- Linking Prenatal Environmental Exposures to Lifetime Health with Epigenome-Wide Association Studies: State-of-the-Science Review and Future Recommendations.Environmental health perspectives · 2023Review
- Article
- Metals Exposures and DNA Methylation: Current Evidence and Future Directions.Current environmental health reports · 2022Review
- Global DNA Methylation in Cord Blood as a Biomarker for Prenatal Lead and Antimony Exposures.Toxics · 2022Article
- Methylmercury-induced DNA methylation-From epidemiological observations to experimental evidence.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
28 authors at 14 institutions in 9 countries.
Manuel LozanoPreventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine Department, Universitat de València, Valencia, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain. Electronic address: manuel.lozano@uv.es.
Paul YousefiMRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Karin BrobergUnit of Metals and Health, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden; Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.
Raquel Soler-BlascoEpidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain.
Chihiro MiyashitaCenter for Environmental and Health Sciences, Hokkaido University, Hokkaido, Japan.
Giancarlo PesceINSERM UMR1018, Université Paris-Saclay, UVSQ, Centre for Epidemiology and Public Health (CESP), Villejuif, France.
Woo Jin KimDepartment of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon, South Korea.
Mohammad RahmanDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, United States.
Kelly M BakulskiSchool of Public Health, University of Michigan, Ann Arbor, MI, USA.
Line S HaugNorwegian Institute of Public Health, Division of Climate and Environment, Oslo, Norway.
Atsuko Ikeda-ArakiCenter for Environmental and Health Sciences, Hokkaido University, Hokkaido, Japan; Faculty of Health Sciences, Hokkaido University, Hokkaido, Japan.
Guy HuelINSERM UMR1018, Université Paris-Saclay, UVSQ, Centre for Epidemiology and Public Health (CESP), Villejuif, France.
Jaehyun ParkInterdisciplinary Program of Bioinformatics, College of Natural Sciences, Seoul National University, Seoul, South Korea.
Caroline ReltonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Martine VrijheidSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain.
Sheryl Rifas-ShimanDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, United States.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, United States.
John F DouSchool of Public Health, University of Michigan, Ann Arbor, MI, USA.
Reiko KishiCenter for Environmental and Health Sciences, Hokkaido University, Hokkaido, Japan.
Kristine B GutzkowNorwegian Institute of Public Health, Division of Climate and Environment, Oslo, Norway.
Isabella Annesi-MaesanoINSERM UMR1302, Montpellier University, Insitut Desbrest d'Épidémiologie et de Santé Publique (IDESP), Montpellier, France.
Sungho WonInterdisciplinary Program of Bioinformatics, College of Natural Sciences, Seoul National University, Seoul, South Korea; Department of Public Health Sciences, Seoul National University, Seoul, South Korea.
Marie-France HivertDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, United States; Diabetes Unit, Massachusetts General Hospital, Boston, MA, United States.
M Daniele FallinBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Marina VafeiadiDepartment of Social Medicine, School of Medicine, University of Crete, Heraklion, Greece.
Ferran BallesterEpidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; School of Nursing, Universitat de València, Valencia, Spain.
Mariona BustamanteSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain.
Sabrina LlopEpidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Harvard University · USHokkaido Information University · JPInserm · FRUniversitat de València · ESNorwegian Institute of Public Health · NOSeoul National University · KRUniversitat Pompeu Fabra · ESUniversity of Bristol · GBUniversity of Michigan · USJohns Hopkins University · USKangwon National University · KRKarolinska Institutet · SEUniversitat Jaume I · ESUniversity of Crete · GR
Funding
Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0MPre- and Peri-natal Predictors of Childhood ObesityR37HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2012 to 2015
$4.5MPrenatal exposure to metals and risk for Autism Spectrum Disorder in MARBLES and EARLIR01ES025531 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI VOLK, HEATHER E · 2016 to 2020
$3.2MEarly Life DNA Methylation and Childhood Allergic DiseaseR01HL111108 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMEO, DAWN L · 2013 to 2016
$3.0MNovel Epigenomic Biomarkers of Prenatal Risk Factors, and Childhood ObesityR01NR013945 · NINR · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA · 2013 to 2015
$1.6MGENETIC AND ENVIRONMENTAL FACTORS IN CHILDHOOD RESPIRATORY HEALTHZ01ES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE JOAN · 1996 to 2008
$537kBiotechnology and Biological Sciences Research Council BB/I025263/1Biotechnology and Biological Sciences Research Council BB/I025751/1Intramural NIH HHS Z01 ES049019Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013_1Medical Research Council MC_UU_12013/2Medical Research Council MC_UU_12013_2Medical Research Council MC_UU_12013/5Medical Research Council MC_UU_12013_5Medical Research Council MC_UU_12013/8Medical Research Council MC_UU_12013_8NHLBI NIH HHS R01 HL111108NICHD NIH HHS R37 HD034568NIEHS NIH HHS N01 ES075558NIEHS NIH HHS R01 ES025531NINDS NIH HHS U01 NS047537NINR NIH HHS R01 NR013945Wellcome TrustWellcome Trust 102215/2/13/2Wellcome Trust WT088806
Abstract
Mercury (Hg) is a ubiquitous heavy metal that originates from both natural and anthropogenic sources and is transformed in the environment to its most toxicant form, methylmercury (MeHg). Recent studies suggest that MeHg exposure can alter epigenetic modifications during embryogenesis. In this study, we examined associations between prenatal MeHg exposure and levels of cord blood DNA methylation (DNAm) by meta-analysis in up to seven independent studies (n = 1462) as well as persistence of those relationships in blood from 7 to 8 year-old children (n = 794). In cord blood, we found limited evidence of differential DNAm at cg24184221 in MED31 (β = 2.28 × 10
Indexed as
MercuryMethylmercury CompoundsPrenatal Exposure Delayed EffectsChildChild, PreschoolDNA MethylationFemaleFetal BloodHumansMediator ComplexPregnancyProspective StudiesMED31 protein, humanMediator ComplexMercuryMethylmercury CompoundsALSPACDNA methylationHELIX studyMercuryMethylmercuryPACEPrenatal exposure
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.