Evidence map›Paper›PMID 34562443›Full record

ArticleThe Journal of pediatrics2022

The Prevalence of Elevated Alanine Aminotransferase Levels Meeting Clinical Action Thresholds in Children with Obesity in Primary Care Practice.

Stephanie J Wu, Jeanne A Darbinian, Jeffrey B Schwimmer, Elizabeth L Yu, Nirmala D Ramalingam, Louise C Greenspan, Joan C Lo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Stephanie J WuDepartment of Medicine, Kaiser Permanente Oakland Medical Center, Oakland, CA.
Jeanne A DarbinianDivision of Research, Kaiser Permanente Northern California, Oakland, CA.
Jeffrey B SchwimmerDepartment of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, CA; Department of Gastroenterology, Rady Children's Hospital, San Diego, CA.
Elizabeth L YuDepartment of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, CA; Department of Gastroenterology, Rady Children's Hospital, San Diego, CA.
Nirmala D RamalingamDepartment of Medicine, Kaiser Permanente Oakland Medical Center, Oakland, CA.
Louise C GreenspanKaiser Permanente San Francisco Medical Center, San Francisco, CA; The Permanente Medical Group, Oakland, CA.
Joan C LoDivision of Research, Kaiser Permanente Northern California, Oakland, CA; The Permanente Medical Group, Oakland, CA.
Kaiser Permanente · USKaiser Permanente Oakland Medical Center · USUniversity of California San Diego · USKaiser Permanente San Francisco Medical Center · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
NCATS NIH HHS UL1 TR001442
6 · The paper itself

Abstract

Using a clinically actionable threshold for alanine aminotransferase to define suspected nonalcoholic fatty liver disease in US children with obesity, the risk of suspected nonalcoholic fatty liver disease was highest for Asian and Hispanic race/ethnicity, male sex, and severe obesity.

Indexed as

AdolescentAlanine TransaminaseBiomarkersChildFemaleHumansMaleNon-alcoholic Fatty Liver DiseaseObesityPrevalenceAlanine TransaminaseBiomarkersalanine aminotransferaseALTchildrenethnicityNAFLDnonalcoholic fatty liver diseaseobesityrace

Identifiers

PMID34562443
PMCPMC8841387
OpenAlexW3204195086

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.