Evidence map›Paper›PMID 34562363›Full record

ArticleCell2021

Structural basis and regulation of the reductive stress response.

Andrew G Manford, Elijah L Mena, Karen Y Shih, Christine L Gee, Rachael McMinimy, Brenda Martínez-González, Rumi Sherriff, Brandon Lew, Madeline Zoltek, Fernando Rodríguez-Pérez and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 138 citations in OpenAlex.

  1. Proteasomal surveillance of exposed cysteines.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Review
  4. Redox signals and oxidative stress in the control of mitochondrial protein import.Protein science : a publication of the Protein Society · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Localized heme sensing through a ternary molecular glue.bioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Quality control of protein import into mammalian mitochondria.Protein science : a publication of the Protein Society · 2026
    Review
  11. Function and regulation of the mitochondrial stress response.Nature structural & molecular biology · 2026
    Review
  12. Induced proximity-based therapeutic modalities.Nature reviews. Drug discovery · 2026
    Review
  13. Review
  14. Article
  15. Reductive stress in cancer immunology and targeted therapy.Acta biochimica et biophysica Sinica · 2026
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Andrew G ManfordDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA.
Elijah L MenaDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA.
Karen Y ShihDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA.
Christine L GeeDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA.
Rachael McMinimyDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Brenda Martínez-GonzálezDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Rumi SherriffDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Brandon LewDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA.
Madeline ZoltekDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Fernando Rodríguez-PérezDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Makda WoldesenbetDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
John KuriyanDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA; California Institute for Quantitative Biosciences (QB3), University of California at Berkeley, Berkeley, CA 94720, USA; Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Chemistry, University of California at Berkeley, Berkeley, CA 94720, USA.
Michael RapeDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA; California Institute for Quantitative Biosciences (QB3), University of California at Berkeley, Berkeley, CA 94720, USA. Electronic address: mrape@berkeley.edu.
University of California, Berkeley · USHoward Hughes Medical Institute · USQB3 · US

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Ritimukta Sarangi · 2020 to 2026
$43.3M
THE MOLECULAR BASIS OF CELL FUNCTIONT32GM007232 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BILDER, DAVID, UNAL, ELCIN · 1985 to 2022
$36.4M
Automated High-Throughput, High-Content Confocal/Wide-Field Microscope SystemS10OD021828 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI WEST, MARY · 2017 to 2017
$1.0M
LTQ XL Linear Quadrupole Ion Trap Mass SpectrometerS10RR025622 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI KOHLSTAEDT, LORI · 2009 to 2009
$463k
Howard Hughes Medical InstituteNCRR NIH HHS S10 RR025622NIGMS NIH HHS P30 GM133894NIGMS NIH HHS T32 GM007232NIH HHS S10 OD021828
6 · The paper itself

Abstract

Although oxidative phosphorylation is best known for producing ATP, it also yields reactive oxygen species (ROS) as invariant byproducts. Depletion of ROS below their physiological levels, a phenomenon known as reductive stress, impedes cellular signaling and has been linked to cancer, diabetes, and cardiomyopathy. Cells alleviate reductive stress by ubiquitylating and degrading the mitochondrial gatekeeper FNIP1, yet it is unknown how the responsible E3 ligase CUL2

Indexed as

Stress, PhysiologicalAmino AcidsAnimalsCarrier ProteinsCell Cycle ProteinsCell LineFemaleHumansIonsMiceMutant ProteinsMutationProtein BindingProtein StabilityReactive Oxygen SpeciesStructure-Activity RelationshipAmino AcidsCarrier ProteinsCell Cycle ProteinsFem1b protein, mouseFNIP1 protein, mouseIonsMutant ProteinsReactive Oxygen SpeciesUbiquitin-Protein Ligase ComplexesZincBEX2BEX3CUL2FEM1Bmitochondriaoxidative phosphorylationreactive oxygen speciesreductive stressubiquitin

Identifiers

PMID34562363
PMCPMC8810291
OpenAlexW3202044524

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.