Evidence map›Paper›PMID 34562238›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Generation and Analysis of Mosaic Spinal Cord Organoids Derived from Mouse Embryonic Stem Cells.

Carina Jägers, Henk Roelink

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Towards 3D Bioprinted Spinal Cord Organoids.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Carina JägersDepartment of Molecular and Cell Biology, UC Berkeley, Berkeley, CA, USA.
Henk RoelinkDepartment of Molecular and Cell Biology, UC Berkeley, Berkeley, CA, USA. roelink@berkeley.edu.
University of California, Berkeley · US

Funding

Sonic Hedgehog is a Calcium-regulated Zinc peptidaseR01GM117090 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROELINK, HENK · 2016 to 2022
$1.9M
NIGMS NIH HHS R01 GM117090
6 · The paper itself

Abstract

Three central cell populations play roles in morphogen action, the cells that produce, the cells that distribute, and the cells that respond to the morphogen. Taking advantage of the properties of embryonic stem cell to aggregate and readily differentiate into neural progenitor tissue, we describe an approach using genetically modified murine stem cell lines to individually address the contribution of these cells in the establishment and response to a morphogenetic gradient in mosaic spinal cord organoids.

Indexed as

Mouse Embryonic Stem CellsOrganoidsAnimalsMiceSignal TransductionSpinal CordEmbryonic stem cellsGenetic mosaicismNeural developmentNon-cell autonomous Sonic Hedgehog signalingSpinal cord organoids

Identifiers

PMID34562238
PMCPMC10114600
OpenAlexW3200685958

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.