Evidence map›Paper›PMID 34562105›Full record

Observational studyLung2021

4D Electromagnetic Navigation Bronchoscopy for the Sampling of Pulmonary Lesions: First European Real-Life Experience.

Filippo Patrucco, Matteo Daverio, Chiara Airoldi, Zeno Falaschi, Vittorio Longo, Francesco Gavelli, Renzo Luciano Boldorini, Piero Emilio Balbo

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Lung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Filippo PatruccoRespiratory Diseases Unit, Medical Department, AOU Maggiore Della Carità, C.so Mazzini 18, 28100, Novara, Italy. filippo.patrucco@maggioreosp.novara.it.ORCID 0000-0002-4794-8734
Matteo DaverioRespiratory Diseases Unit, Medical Department, AOU Maggiore Della Carità, C.so Mazzini 18, 28100, Novara, Italy.
Chiara AiroldiDepartment of Translational Medicine, University of Piemonte Orientale, Novara, Italy.ORCID 0000-0002-9114-5816
Zeno FalaschiRadiodiagnostics, Department of Diagnosis and Treatment Services, AOU Maggiore Della Carità, Novara, Italy.ORCID 0000-0003-3583-2731
Vittorio LongoRadiodiagnostics, Department of Diagnosis and Treatment Services, AOU Maggiore Della Carità, Novara, Italy.
Francesco GavelliDepartment of Translational Medicine, University of Piemonte Orientale, Novara, Italy.ORCID 0000-0002-0581-245X
Renzo Luciano BoldoriniPathology Unit, University of Piemonte Orientale, AOU Maggiore Della Carità, Novara, Italy.
Piero Emilio BalboRespiratory Diseases Unit, Medical Department, AOU Maggiore Della Carità, C.so Mazzini 18, 28100, Novara, Italy.
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe use of Electromagnetic navigation bronchoscopy (ENB) for the diagnosis of pulmonary peripheral lesions is still debated due to its variable diagnostic yield; a new 4D ENB system, acquiring inspiratory and expiratory computed tomography (CT) scans, overcomes respiratory motion and uses tracked sampling instruments, reaching higher diagnostic yields. We aimed at evaluating diagnostic yield and accuracy of a 4D ENB system in sampling pulmonary lesions and at describing their influencing factors.

methodsWe conducted a three-year retrospective observational study including all patients with pulmonary lesions who underwent 4D ENB with diagnostic purposes; all the factors potentially influencing diagnosis were recorded.

results103 ENB procedures were included; diagnostic yield and accuracy were, respectively, 55.3% and 66.3%. We reported a navigation success rate of 80.6% and a diagnosis with ENB was achieved in 68.3% of cases; sensitivity for malignancy was 61.8%. The majority of lesions had a bronchus sign on CT, but only the size of lesions influenced ENB diagnosis (p < 0.05). Transbronchial needle aspiration biopsy was the most used tool (93.2% of times) with the higher diagnostic rate (70.2%). We reported only one case of pneumothorax.

conclusionThe diagnostic performance of a 4D ENB system is lower than other previous navigation systems used in research settings. Several factors still influence the reachability of the lesion and therefore diagnostic yield. Patient selection, as well as the multimodality approach of the lesion, is strongly recommended to obtain higher diagnostic yield and accuracy, with a low rate of complications.

Indexed as

BronchoscopyLung NeoplasmsBronchiElectromagnetic PhenomenaHumansLungTomography, X-Ray ComputedBronchus SignElectromagnetic Navigation BronchoscopyLung Cancer DiagnosisNavigation SystemPulmonary MassesPulmonary Nodule

Identifiers

PMID34562105
PMCPMC8510943
OpenAlexW3200953366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.