Evidence map›Paper›PMID 34562095›Full record

ArticleThe American journal of clinical nutrition2022

Maternal diet quality during pregnancy and child cognition and behavior in a US cohort.

Hiya A Mahmassani, Karen M Switkowski, Tammy M Scott, Elizabeth J Johnson, Sheryl L Rifas-Shiman, Emily Oken, Paul F Jacques

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hiya A MahmassaniDorothy J and Gerald R Friedman School of Nutrition and Science Policy, Tufts University, Boston, MA, USA.
Karen M SwitkowskiDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Tammy M ScottDorothy J and Gerald R Friedman School of Nutrition and Science Policy, Tufts University, Boston, MA, USA.
Elizabeth J JohnsonDorothy J and Gerald R Friedman School of Nutrition and Science Policy, Tufts University, Boston, MA, USA.ORCID 0000-0002-8508-0032
Sheryl L Rifas-ShimanDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.ORCID 0000-0003-0033-920X
Emily OkenDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.ORCID 0000-0003-2513-3339
Paul F JacquesDorothy J and Gerald R Friedman School of Nutrition and Science Policy, Tufts University, Boston, MA, USA.ORCID 0000-0001-5567-3147
Tufts University · USHarvard University · US

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
NIH HHS R01 HD034568NIH HHS UH3 OD023286
6 · The paper itself

Abstract

backgroundMaternal intake of several nutrients during pregnancy is linked to offspring cognition. The relation between maternal dietary patterns and offspring cognition is less established.

objectivesWe aimed to examine associations of maternal diet quality during pregnancy with child cognition and behavior.

methodsAmong 1580 mother-child pairs in Project Viva, a prospective prebirth cohort, we assessed maternal diet during pregnancy using FFQs and evaluated diet quality using versions modified for pregnancy of the Mediterranean Diet Score (MDS-P) and Alternate Healthy Eating Index (AHEI-P). Child cognitive and behavioral outcomes were assessed using standardized tests and questionnaires at infancy and in early and mid-childhood. We conducted multivariable linear regression analyses.

resultsMothers were predominantly white, college-educated, and nonsmokers. After adjustment for child age and sex and maternal sociodemographic and lifestyle characteristics, maternal high (6-9) compared with low (0-3) MDS-P during pregnancy was associated with higher child Kaufman Brief Intelligence Test (KBIT-II) nonverbal (mean difference for first trimester: 4.54; 95% CI: 1.53, 7.56) and verbal scores (3.78; 95% CI: 1.37, 6.19) and lower Behavioral Rating Inventory of Executive Function (BRIEF) Metacognition Index (-1.76; 95% CI: -3.25, -0.27), indicating better intelligence and fewer metacognition problems in mid-childhood. Maternal Q4 compared with Q1 AHEI-P during pregnancy was associated with higher Wide Range Assessment of Visual Motor Abilities matching scores in early childhood (mean difference for first trimester: 2.79; 95% CI: 0.55, 5.04) and higher KBIT-II verbal scores (2.59; 95% CI: 0.13, 5.04) and lower BRIEF Global Executive Composite scores in mid-childhood (-1.61; 95% CI: -3.20, -0.01), indicating better visual spatial skills, verbal intelligence, and executive function.

conclusionsMaternal intake of a better-quality diet during pregnancy was associated with better visual spatial skills in the offspring at early childhood and with better intelligence and executive function in the offspring at mid-childhood.

Indexed as

Maternal Nutritional Physiological PhenomenaAdultChildChild BehaviorChild DevelopmentChild, PreschoolCognitionDiet, HealthyDiet SurveysExecutive FunctionFemaleHumansInfantInfant, NewbornIntelligenceLinear ModelsAlternate Healthy Eating Indexbirth cohortchildhood cognitioncognitive developmentearly developmentearly-life nutritionmaternal diet during pregnancyMediterranean dietprenatal nutritionprogramming

Identifiers

PMID34562095
PMCPMC8755080
OpenAlexW3199482928

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.