Evidence map›Paper›PMID 34561486›Full record

ArticleScientific reports2021

Covalent functionalization of polypropylene filters with diazirine-photosensitizer conjugates producing visible light driven virus inactivating materials.

T J Cuthbert, S Ennis, S F Musolino, H L Buckley, M Niikura, J E Wulff, C Menon

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. The Versatility of Diazirines: Properties, Synthetic and Modern Applications.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

T J CuthbertDepartment of Health Sciences and Technology, ETH Zürich, 8008, Zürich, Switzerland. tyler.cuthbert@hest.ethz.ch.
S EnnisFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
S F MusolinoDepartment of Chemistry, University of Victoria, Victoria, BC, V8W 3V6, Canada.
H L BuckleyDepartment of Civil Engineering, University of Victoria, Victoria, BC, V8W 3V6, Canada.
M NiikuraFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
J E WulffDepartment of Chemistry, University of Victoria, Victoria, BC, V8W 3V6, Canada.
C MenonDepartment of Health Sciences and Technology, ETH Zürich, 8008, Zürich, Switzerland.
University of Victoria · CAETH Zurich · CHSimon Fraser University · CA

Funding

Mitacs #IT17318
6 · The paper itself

Abstract

The SARS-CoV-2 pandemic has highlighted the weaknesses of relying on single-use mask and respirator personal protective equipment (PPE) and the global supply chain that supports this market. There have been no major innovations in filter technology for PPE in the past two decades. Non-woven textiles used for filtering PPE are single-use products in the healthcare environment; use and protection is focused on preventing infection from airborne or aerosolized pathogens such as Influenza A virus or SARS-CoV-2. Recently, C-H bond activation under mild and controllable conditions was reported for crosslinking commodity aliphatic polymers such as polyethylene and polypropylene. Significantly, these are the same types of polymers used in PPE filtration systems. In this report, we take advantage of this C-H insertion method to covalently attach a photosensitizing zinc-porphyrin to the surface of a melt-blow non-woven textile filter material. With the photosensitizer covalently attached to the surface of the textile, illumination with visible light was expected to produce oxidizing

Indexed as

LightCOVID-19DiazomethanePhotosensitizing AgentsPolypropylenesSARS-CoV-2DiazomethanePhotosensitizing AgentsPolypropylenes

Identifiers

PMID34561486
PMCPMC8463589
OpenAlexW3201058953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.