ArticleScientific reports2021
Effect of 1-MHz ultrasound on the proinflammatory interleukin-6 secretion in human keratinocytes.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- A review on plant-mediated synthesis of AgNPs and their formulations for wound healing application.Molecular biology reports · 2025Review
- Low-intensity pulsed ultrasound induces multifaced alterations in chromosome segregation, cytoskeletal filaments and cell junctions.Scientific reports · 2025Article
- Harnessing Ultrasonic Technologies to TreatMolecules (Basel, Switzerland) · 2025Review
- Radiofrequency Currents Modulate Inflammatory Processes in Keratinocytes.International journal of molecular sciences · 2024Article
- Musculoskeletal Biomaterials: Stimulated and Synergized with Low Intensity Pulsed Ultrasound.Journal of functional biomaterials · 2023Review
- Cellular and Molecular Processes in Wound Healing.Biomedicines · 2023Review
- Enhancing Targeted Therapy in Breast Cancer by Ultrasound-Responsive Nanocarriers.International journal of molecular sciences · 2023Review
- Diet, sleep, and exercise in inflammatory skin diseases.Our dermatology online · 2023Article
- Cannabidiolic acid in Hemp Seed Oil Table Spoon and Beyond.Molecules (Basel, Switzerland) · 2022Article
- The photoprotective properties of α-tocopherol phosphate against long-wave UVA1 (385 nm) radiation in keratinocytes in vitro.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratinocytes, the main cell type of the skin, are one of the most exposed cells to environmental factors, providing a first defence barrier for the host and actively participating in immune response. In fact, keratinocytes express pattern recognition receptors that interact with pathogen associated molecular patterns and damage associated molecular patterns, leading to the production of cytokines and chemokines, including interleukin (IL)-6. Herein, we investigated whether mechanical energy transported by low intensity ultrasound (US) could generate a mechanical stress able to induce the release of inflammatory cytokine such IL-6 in the human keratinocyte cell line, HaCaT. The extensive clinical application of US in both diagnosis and therapy suggests the need to better understand the related biological effects. Our results point out that US promotes the overexpression and secretion of IL-6, associated with the activation of nuclear factor-κB (NF-κB). Furthermore, we observed a reduced cell viability dependent on exposure parameters together with alterations in membrane permeability, paving the way for further investigating the molecular mechanisms related to US exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.