Evidence map›Paper›PMID 34561445›Full record

ArticleNature communications2021

A longitudinal sampling study of transcriptomic and epigenetic profiles in patients with thrombocytopenia syndrome.

Yafen Wang, Shaoqing Han, Ruoxi Ran, Anling Li, Huanyu Liu, Mingjun Liu, Yongwei Duan, Xiong Zhang, Zhigang Zhao, Shihui Song and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

  1. pgRNA-mEpigenetics · 2026
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  13. NGenomics, proteomics & bioinformatics · 2023
    Review
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  19. InferringGenes · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Yafen Wang *College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China.
Shaoqing Han *College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China.
Ruoxi Ran *Department of Clinical Laboratory, Center for Gene Diagnosis, and Program of Clinical Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Anling Li *Department of Clinical Laboratory, Center for Gene Diagnosis, and Program of Clinical Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Huanyu LiuDepartment of Obstetrics and Gynecology, Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Mingjun LiuDepartment of Clinical Laboratory, Center for Gene Diagnosis, and Program of Clinical Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yongwei DuanDepartment of Clinical Laboratory, Center for Gene Diagnosis, and Program of Clinical Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xiong ZhangCollege of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China.
Zhigang ZhaoDepartment of Emergency, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Shihui SongDepartment of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Xiaocheng WengCollege of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China. xcweng@whu.edu.cn.ORCID 0000-0002-0605-8495
Song-Mei LiuDepartment of Clinical Laboratory, Center for Gene Diagnosis, and Program of Clinical Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China. smliu@whu.edu.cn.ORCID 0000-0001-9276-6078
Xiang ZhouCollege of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China. xzhou@whu.edu.cn.ORCID 0000-0002-1829-9368
Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is a novel tick-borne infectious disease caused by a new type of SFTS virus (SFTSV). Here, a longitudinal sampling study is conducted to explore the differences in transcript levels after SFTSV infection, and to characterize the transcriptomic and epigenetic profiles of hospitalized patients. The results reveal significant changes in the mRNA expression of certain genes from onset to recovery. Moreover, m

Indexed as

Epigenesis, GeneticTranscriptomeAgedAlanine TransaminaseAntiviral AgentsAspartate AminotransferasesCreatinineEpigenomicsFemaleGene Expression ProfilingHospitalizationHumansLongitudinal StudiesMaleMiddle AgedPhlebovirusAlanine TransaminaseAntiviral AgentsAspartate AminotransferasesCreatinine

Identifiers

PMID34561445
PMCPMC8463551
OpenAlexW3201427513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.