Trial reportNature communications2021
Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis.
2 registry-linked trialsAbstract readClinical Trial, Phase IClinical Trial, Phase II
In one paragraph
Trial report in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 91 papers.
0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
StereoTactic Arrhythmia Radiotherapy in the NetherLands no. 2
NCT06299176 phase1enrolling by invitationnot on this mapstarted 2025, after this paper: background citation
Phase 1 Feasibility and Safety of Whole Heart Radiotherapy for End-stage Heart Failure: First In-human Treatments
Who cites it
91 citing papers in PubMed.
- Implementing stereotactic arrhythmia radioablation with STOPSTORM.eu consortium support: intermediate results of a prospective Israeli single-institutional trial.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025Trial
- Dose escalation for stereotactic arrhythmia radioablation of recurrent ventricular tachyarrhythmia - a phase II clinical trial.Radiation oncology (London, England) · 2023Trial
- Non-invasive stereotactic arrhythmia radiotherapy for ventricular tachycardia: results of the prospective STARNL-1 trial.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Trial
- Effects of X-ray and carbon-ion beam irradiation on pathological cardiac remodeling in mice.Journal of radiation research · 2026Article
- Development of a prospective clinical workflow for proton beam therapy of ventricular tachycardia.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- Stereotactic arrhythmia radioablation for ventricular tachycardia: Mechanisms, workflow, outcomes, and future directions.Heart rhythm O2 · 2026Review
- Extended follow-up of stereotactic body radiation therapy for refractory ventricular arrhythmias.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Stereotactic Body Radiotherapy for Refractory Ventricular Tachycardia: From Serendipity to Precision Biological Ablation.Reviews in cardiovascular medicine · 2026Review
- Failure modes and effects analysis of LINAC-based stereotactic arrhythmia radioablation categorized by segmental targets.Radiation oncology (London, England) · 2026Article
- Longitudinal Trends in Myocardial Metabolic Uptake Following Stereotactic Arrhythmia Radioablation Using 2-Deoxy-2-[International journal of radiation oncology, biology, physics · 2026Article
- Prioritizing Discovery and Advancements in Arrhythmia Therapies: NIH/NHLBI Workshop.JACC. Clinical electrophysiology · 2026Review
- Radiation induces diffuse extracellular remodeling of healthy myocardium in a dose- and time-dependent manner without a dense ablative effect.Heart rhythm · 2026Article
- Position Statement on the Diagnosis and Treatment of Electrical Storm - 2026.Arquivos brasileiros de cardiologia · 2026Article
- Standardized processing of explanted hearts after stereotactic arrhythmia radiotherapy (Bio-STAR): a STOPSTORM framework and first human findings.European heart journal open · 2026Article
- Cardiac radiotherapy-induced epigenetic memory underlies electrophysiologic and metabolic reprogramming.The Journal of clinical investigation · 2026Article
- Low-Dose Cardiac Radiation Improves Electrical Function and Reduces Ventricular Arrhythmogenesis in Mice With Nonischemic Cardiomyopathy.JACC. Clinical electrophysiology · 2026Article
- Progressive myocardial metabolic dysfunction after stereotactic arrhythmia radioablation for ventricular tachycardia in hypertrophic cardiomyopathy: a serial multimodality imaging case report.European heart journal. Case reports · 2026Article
- Early and Late Myocardial Effects of Proton Beam Cardiac Radioablation: Insights From Gene Expression Analysis.JACC. Clinical electrophysiology · 2026Article
- Article
- Stereotactic radioablation for ventricular tachycardia in patients untreatable by catheter ablation: evidence of efficacy, safety, and impact on coronary arteries.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
19 authors.
David M ZhangCenter for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0002-4054-3312
Rachita NavaraCenter for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0002-6183-4258
Tiankai YinDepartment of Medicine, Cardiovascular Division, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0003-0584-8791
Jeffrey SzymanskiDepartment of Radiation Oncology, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.
Uri GoldsztejnDepartment of Medicine, Cardiovascular Division, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0001-7040-7007
Camryn KenkelDepartment of Medicine, Cardiovascular Division, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.
Adam LangDepartment of Pathology, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.
Cedric MpoyDepartment of Radiation Oncology, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.
Catherine E LipovskyDepartment of Medicine, Cardiovascular Division, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.
Yun QiaoDepartment of Medicine, Cardiovascular Division, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.
Stephanie HicksDepartment of Medicine, Cardiovascular Division, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.
Gang LiDepartment of Medicine, Cardiovascular Division, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.
Kaitlin M S MooreCenter for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.
Carmen BergomCenter for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0002-0886-5055
Buck E RogersDepartment of Radiation Oncology, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.
Clifford G RobinsonCenter for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.
Phillip S CuculichCenter for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.
Julie K SchwarzCenter for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0003-2407-7531
Stacey L RentschlerCenter for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of Medicine, Saint Louis, MO, USA. Stacey.Rentschler@wustl.edu.ORCID http://orcid.org/0000-0002-1744-1238
Funding
NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8MUCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4MA 3D IN VITRO DISEASE MODEL OF ATRIAL CONDUCTIONUH3HL141800 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CURIEL, DAVID TERRY, GEORGE, STEVEN CARL · 2019 to 2021
$4.0MWNT SIGNALING IN CARDIAC CONDUCTION AND ARRHYTHMOGENESISR01HL130212 · NHLBI · WASHINGTON UNIVERSITY · PI RENTSCHLER, STACEY LYNN · 2016 to 2024
$4.0MGenetic Modifiers of Radiation Therapy-Induced CardiotoxicityR01HL147884 · NHLBI · WASHINGTON UNIVERSITY · PI BERGOM, CARMEN · 2019 to 2023
$2.3MTraining in Integrative and Systems Biology of Cardiovascular DiseaseT32HL134635 · NHLBI · WASHINGTON UNIVERSITY · PI NERBONNE, JEANNE M. · 2017 to 2021
$1.8MPURCHASE OF AN IMAGE-GUIDED SMALL-ANIMAL IRRADIATORS10OD020136 · OD · WASHINGTON UNIVERSITY · PI HALLAHAN, DENNIS E · 2015 to 2015
$600kNHLBI NIH HHS R01 HL130212NHLBI NIH HHS R01 HL147884NHLBI NIH HHS T32 HL134635NHLBI NIH HHS UH3 HL141800NIGMS NIH HHS K12 GM068524NIGMS NIH HHS T32 GM007200NIH HHS S10 OD020136ODCDC CDC HHS S10 OD020136
Abstract
Cardiac radiotherapy (RT) may be effective in treating heart failure (HF) patients with refractory ventricular tachycardia (VT). The previously proposed mechanism of radiation-induced fibrosis does not explain the rapidity and magnitude with which VT reduction occurs clinically. Here, we demonstrate in hearts from RT patients that radiation does not achieve transmural fibrosis within the timeframe of VT reduction. Electrophysiologic assessment of irradiated murine hearts reveals a persistent supraphysiologic electrical phenotype, mediated by increases in Na
Indexed as
Action PotentialsAnimalsConnexin 43Dose-Response Relationship, RadiationElectrocardiographyEndomyocardial FibrosisFemaleGene Expression RegulationHeartHeart Conduction SystemHeart RateHumansMaleMiceNAV1.5 Voltage-Gated Sodium ChannelSignal TransductionConnexin 43GJA1 protein, humanNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, human
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
NCT05439031ClinicalTrials.gov
NCT06299176ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.