ArticleProceedings of the National Academy of Sciences of the United States of America2021
ATF6 is essential for human cone photoreceptor development.
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
What it found
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Retinal Organoids from Induced Pluripotent Stem Cells of Patients with Inherited Retinal Diseases: A Systematic Review.Stem cell reviews and reports · 2025Pooled it
- Regulation of the endoplasmic reticulum stress sensor ATF6α through multiple oxidoreductases in the ER.iScience · 2026Article
- Activating transcription factor 6 is involved in the beneficial effects of growth hormone-releasing hormone antagonists in the corneal endothelium.Frontiers in ophthalmology · 2026Article
- Tempol Mitigates Cisplatin-Induced Retinopathy by Modulating ER Stress, Enhancing Autophagy, and Preserving Neurotrophic Support.Molecular neurobiology · 2025Article
- Loss of BAP31 Is Detrimentally Aging Photoreceptors Through ER Stress-Mediated Retinal Degeneration.Cells · 2025Article
- Targeting ATF6 reduces pathological neovascularization and improves visual outcomes in retinal disease models.Scientific reports · 2025Article
- Genome analyses suggest recent speciation and postglacial isolation in the Norwegian lemming.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Retinal Organoids: Innovative Tools for Understanding Retinal Degeneration.International journal of molecular sciences · 2025Review
- Article
- Endoplasmic Reticulum Stress in Acute Myeloid Leukemia: Pathogenesis, Prognostic Implications, and Therapeutic Strategies.International journal of molecular sciences · 2025Review
- Mutations in unfolded protein response regulator ATF6 cause hearing and vision loss syndrome.The Journal of clinical investigation · 2025Article
- Dysregulation of Retinal and Photoreceptor Structural Integrity Genes in ATF6Advances in experimental medicine and biology · 2025Article
- Review
- The endoplasmic reticulum: Homeostasis and crosstalk in retinal health and disease.Progress in retinal and eye research · 2024Review
- Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases.Stem cell research & therapy · 2023Review
- Mitochondria and Endoplasmic Reticulum Stress in Retinal Organoids from Patients with Vision Loss.The American journal of pathology · 2023Article
- Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators.ACS chemical biology · 2023Article
- Overexpression of Nfe2l1 increases proteasome activity and delays vision loss in a preclinical model of human blindness.Science advances · 2023Article
- Imbalanced unfolded protein response signaling contributes to 1-deoxysphingolipid retinal toxicity.Nature communications · 2023Article
- Neuronal p58Cells · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 8 institutions in 3 countries.
Heike KroegerDepartment of Cellular Biology, Franklin College of Arts and Sciences, University of Georgia, Athens, GA 30601; heike.kroeger@uga.edu jlinn@stanford.edu.ORCID 0000-0001-7726-7748
Julia M D GrandjeanDepartment of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037.
Wei-Chieh Jerry ChiangDevelopmental Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa 904-0495, Japan.ORCID 0000-0002-1268-3019
Daphne D BindelsDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093.
Rebecca MasteyDepartment of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226.
Jennifer OkalovaCollege of Pharmacy, Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30601.
Amanda NguyenDepartment of Pathology, Stanford University, Stanford, CA 94305.ORCID 0000-0001-6256-6825
Evan T PowersDepartment of Chemistry, Scripps Research Institute, La Jolla, CA 92037.
Jeffery W KellyDepartment of Chemistry, Scripps Research Institute, La Jolla, CA 92037.
Neil J GrimseyCollege of Pharmacy, Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30601.
Michel MichaelidesUCL Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom.
Joseph CarrollDepartment of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226.ORCID 0000-0002-8640-1029
R Luke WisemanDepartment of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037.ORCID 0000-0001-9287-6840
Jonathan H LinDepartment of Pathology, Stanford University, Stanford, CA 94305; heike.kroeger@uga.edu jlinn@stanford.edu.ORCID 0000-0002-7438-6941
Scripps Research Institute · USUniversity of Georgia · USMedical College of Wisconsin · USMoorfields Eye Hospital · GBOkinawa Institute of Science and Technology Graduate University · JPStanford University · USUniversity of California San Diego · USVA Palo Alto Health Care System · US
Funding
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0MAssessing Photoreceptor Structure and Function in Normal and Diseased RetinaeR01EY017607 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI Joseph Carroll · 2008 to 2026
$8.3MStanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI STEPHEN A BACCUS · 2017 to 2026
$8.0MDiscovering small molecules activators of stress responsive signalingR01AG046495 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI JEFFERY W KELLY, Rockland Luke Wiseman · 2013 to 2026
$6.0MProtein Homeostasis and Proteotoxicity MechanismsR01NS088485 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIN, JONATHAN · 2015 to 2024
$3.0MMolecular Pathology of AchromatopsiaR01EY027335 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIN, JONATHAN · 2017 to 2019
$1.2MAdapting Secretory Proteostasis through Pharmacologic IRE1 ActivationF31AG063489 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI GRANDJEAN, JULIA MARIE DENDLE · 2019 to 2020
$54kEndoplasmic Reticulum Stress in NeurodegenerationI01RX002340 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI JONATHAN LIN · 2017 to 2026
–Cellular and Molecular Mechanisms of Age-Related Retinal DegenerationI01BX002284 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI LIN, JONATHAN · 2014 to 2023
–BLRD VA I01 BX002284NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY017607NEI NIH HHS R01 EY027335NIA NIH HHS F31 AG063489NIA NIH HHS R01 AG046495NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS088485RRD VA I01 RX002340
Abstract
Endoplasmic reticulum (ER) stress and Unfolded Protein Response (UPR) signaling promote the pathology of many human diseases. Loss-of-function variants of the UPR regulator
Indexed as
Activating Transcription Factor 6Color Vision DefectsCone OpsinsGene ExpressionHEK293 CellsHumansInduced Pluripotent Stem CellsOrganoidsRetinaRetinal Cone Photoreceptor CellsVision, OcularActivating Transcription Factor 6ATF6 protein, humanCone OpsinsachromatopsiaATF6 signalingcone photoreceptorsretinal organoidsstem cell biology
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.